Indole derivatives, process for producing the same and medicinal uses of the same

ABSTRACT

A novel compound which is a δ-opioid antagonist having high selectivity and activity, that exhibits immunosuppressive action, antiallergic action, anti-inflammatory action and brain cell-protecting action is disclosed. The compound according to the present invention is an indole derivative represented by the formula (I): ##STR1## and pharmaceutically acceptable acid addition salts thereof. The present invention also provides an immunosuppressive agent, antiallergic agent, anti-inflammatory agent and brain cell-protecting agent comprising the derivative or the salt as an effective ingredient.

This application is a continuation, of application Ser. No. 08/244,198filed as PCT/JP93/01388 Sep. 29, 1993 published as WO94/07896 Apr. 14,1994.

TECHNICAL FIELD

The present invention relates to compounds having affinities to δ-opioidreceptor. δ-opioid receptor relates to analgetic, immune and circulatorysystems (especially blood pressure) and ligands having highselectivities to this receptor can be used as analgesics,immunosuppressive agents (employed in organ transplantation (kidney,liver and heart), skin transplantation, treatment of autoimmune diseases(rheumatism, various allergies and collagen diseases) and the like!,immunopotentiating agents (anti-tumor agents and anti-virus agents),blood pressure-lowering agents and the like.

PRIOR ART

Opioid receptors include three types called μ, δ and κ. Among these,δ-opioid receptor relates various pharmacological effects as mentionedabove. However, the number of agonists and antagonists having highselectivities to this receptor is small and the mechanism has not yetbeen clarified. Recently, a non-peptidic antagonist NTI was discoveredby Portoghese (Portoghese, P. S. et al., J. Med. Chem., 31, 281 (1988);33, 1714 (1990)). Subsequently, synthesis of an antagonist (5'-NTII)which can irreversibly bind to the receptor was reported (Portoghese, P.S. et al., J. Med. Chem. 33, 1547 (1990)). Since a ligand whichirreversibly binds to the receptor is very useful in studying thereceptor, researchers are paying more and more attention to 5'-NTII.However, its antagonist activity and selectivity to δ-opioid receptorare low. Therefore, as a probe for studying the receptor, a ligandhaving higher activity and selectivity is demanded.

On the other hand, participation of endogenous opioid peptides such asenkephalin, and morphine in immune system has been pointed out and it isknown that opioids may possibly be immunopotentiating agents andimmunosuppressive agents. Paying attention to this, the presentinventors studied influence on immune system by NTI. As a result, it wasshown that this compound exhibits immunosuppressive action in vitro andin vivo (Japanese Laid-open Patent Application (Kokai) No. 3-223288).Since currently used immunosuppressive agents have problems intoxicities and side effects, an agent having a low toxicity or having adifferent mechanism of action is demanded. It is expected that δ-opioidantagonist is one of the candidates thereof.

It has recently been discovered that opioids relate to flow of calciumion into cells, which has a relationship with ischemia in brain, andthat opioids have brain cell-protecting action. Thus, use of opioids asa brain cell-protecting agent is more and more expected.

DISCLOSURE OF THE INVENTION

An object of the present invention is to provide a δ-opioid antagonisthaving high antagonist activity and receptor selectivity.

Another object of the present invention is to provide a δ-opioidantagonist having high immunosuppressive action and braincell-protecting action.

To attain the above-mentioned objects, the present inventors intensivelystudied to discover that the compound represented by the formula (I)below has the above-mentioned characteristics, thereby completing thepresent invention. That is, the present invention provides an indolederivative represented by the formula (I): ##STR2## wherein R¹represents C₁ -C₅ alkyl, C₄ -C₆ cycloalkylalkyl, C₅ -C₇cycloalkenylalkyl, aryl, C₁ -C₃ aralkyl, C₄ -C₅ trans-alkenyl, allyl, C₁-C₃ furan-2-ylalkyl or C₁ -C₃ thiophene-2-ylalkyl;

R² represents hydrogen, hydroxy, C₁ -C₅ alkanoyloxy or C₁ -C₅ alkoxy;

R³ represents hydrogen, C₁ -C₅ alkyl, C₁ -C₅ alkanoyl or benzyl;

R⁴ represents hydrogen, C₁ -C₅ alkyl or benzyl; R⁵ and R⁶, the same ordifferent, represent hydrogen, iodine, trifluoromethyl,trifluoromethoxy, cyano, phenyl, C₁ -C₃ hydroxyalkyl, SR⁷, SOR⁷, SO₂ R⁷,(CH₂)_(m) CO₂ R⁷ (wherein m represents an integer of 0-3, R⁷ representsC₁ -C₅ alkyl), SO₂ NR⁸ R⁹, CONR⁸ R⁹, (CH₂)_(n) NR⁸ R⁹ (wherein nrepresents an integer of 1-3, R⁸ and R⁹, the same or different,represent C₁ -C₅ alkyl, or C₄ -C₆ cycloalkylalkyl), isothiocyanato (NCS;bonded to one of 4'-, 6'- and 7'-positions) or nitro (bonded to one of4'-, 6'- and 7'-positions), with the proviso that R⁵ and R⁶ are notsimultaneously hydrogen atoms)

or R⁵ and R⁶ are bonded and cooperatively represent C₃ -C₆ alkylene(with the proviso that one or more hydrogen atoms in the alkylene moietymay be substituted with R¹⁰ (wherein R¹⁰ represents C₁ -C₅ alkyl, C₁ -C₅alkoxy, C₁ -C₅ alkanoyl, C₁ -C₅ hydroxyalkyl, SR⁷, SOR⁷, SO₂ R⁷(CH₂)_(m) CO₂ R⁷, SO₂ NR⁸ R⁹, CONR⁸ R⁹, (CH₂)_(n) NR⁸ R⁹ (wherein m, n,R⁷, R⁸ and R⁹ represent the same meanings as described above,respectively), and with the proviso that said alkylene is bonded tocarbon atoms adjacent to each other on the benzene ring to form a ring)or R⁵ and R⁶ cooperatively represent --S═T--U═V-- (wherein at least oneof S, T, U and V represents nitrogen and the remainders represent CH(with the proviso that the hydrogen may be substituted with said R¹⁰)which is bonded to carbon atoms adjacent to each other on the benzenering to form a ring);

the formula (I) includes (+) isomers, (-) isomers and racemates!

and pharmaceutically acceptable acid addition salts thereof.

The present invention also provides an immunosuppressive agent, a braincell-protecting agent, an antiallergic agent and an anti-inflammatoryagent comprising as an effective ingredient the indole derivative or thepharmaceutically acceptable acid addition salt thereof according to thepresent invention.

The present invention further provides a process for producing theindole derivative or the pharmaceutically acceptable acid addition saltthereof according to the present invention, comprising the step ofreaction of a compound of the formula (III): ##STR3## (wherein R¹, R²and R³ represent the same meanings as described above, respectively)

with a phenylhydrazine derivative of the formula (IV): ##STR4## (whereinR⁴, R⁵ and R⁶ represent the same meanings as described above,respectively)

in the presence of an acid catalyst.

By the present invention, novel indole derivatives which are δ-opioidantagonists having high selectivities and activities, andpharmaceutically acceptable acid addition salts thereof, as well as aprocess for producing the same, were provided. The indole derivativesaccording to the present invention have excellent immunosuppressiveactions, brain cell-protecting actions, antiallergic actions andanti-inflammatory actions.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the change in antagonist action of compounds 173 and 174according to the present invention against DPDPE with time, which wasdetermined by calculating Ke value at 15 minutes, 30 minutes and 1 hourfrom the addition of the test compounds, using MVD.

FIG. 2 shows the change in antagonist action of compound 174 accordingto the present invention against DPDPE in scale enlarged by changing thescale of the ordinate in FIG. 1.

BEST MODE FOR CARRYING OUT THE INVENTION

As mentioned above, the indole derivatives according to the presentinvention are represented by the above-described formula (I).

Among the indole derivatives represented by the above-described formula(I), those in which R⁵ and R⁶ are bonded each other are represented bythe following formula (II): ##STR5## wherein X represents C₃ -C₆alkylene (with the proviso that one or more hydrogen atoms in thealkylene moiety may be substituted with R¹⁰ (wherein R¹⁰ represents C₁-C₅ alkyl, SR⁷, SOR⁷, SO₂ R⁷, (CH₂)_(m) CO₂ R⁷, SO₂ NR⁸ R⁹, CONR⁸ R⁹,(CH₂)_(n) NR⁸ R⁹ (wherein m, n, R⁷, R⁸ and R⁹ represent the samemeanings as mentioned above, respectively), or --S═T--U═V-- (wherein atleast one of S, T, U and V represents nitrogen and the remaindersrepresent CH (with the proviso that the hydrogen may be substituted withsaid R¹⁰) which is bonded to carbon atoms adjacent to each other on thebenzene ring to form a ring), the number of hydrogen atoms substitutedwith R¹⁰ being appropriately selected from the range in which thesubstitution can be carried out!.

Among the indole derivatives represented by the formula (I), thoserepresented by the following formula (IIa) are preferred, wherein R¹,R², R³ and R⁴ have the same meanings as described above, respectively,R⁵ and R⁶ are bonded to form C₄ alkylene with the proviso that one ormore hydrogen atoms in the alkylene moiety may be substituted with R¹⁰(wherein R¹⁰ represents C₁ -C₅ alkyl, C₁ -C₅ alkoxy, C₁ -C₅ alkanoyl, C₁-C₅ hydroxyalkyl, SR⁷, SOR⁷, SO₂ R⁷ (CH₂)_(m) CO₂ R⁷, SO₂ NR⁸ R⁹, CONR⁸R⁹, (CH₂)_(n) NR⁸ R⁹ (wherein m, n, R⁷, R⁸ and R⁹ represent the samemeanings as described above, respectively). ##STR6##

Preferred examples of the acid for forming pharmaceutically acceptableacid addition salts include inorganic acids such as hydrochloric acid,sulfuric acid, hydrobromic acid, hydriodic acid and phosphoric acid;organic carboxylic acids such as acetic acid, lactic acid, citric acid,oxalic acid, glutaric acid, malic acid, tartaric acid, fumaric acid,mandelic acid, maleic acid, benzoic acid and phthalic acid; and organicsulfonic acids such as methanesulfonic acid, ethanesulfonic acid,benzenesulfonic acid, p-toluenesulfonic acid and the like. Among these,hydrochloric acid, phosphoric acid, tartaric acid and methanesulfonicacid are preferred, although not limited thereto.

Compound 1 represented by the formula (I) wherein R¹ iscyclopropylmethyl, R² is hydroxy, R³ is hydrogen, R⁴ is hydrogen and R⁵is 5'-iodine, that is, the compound represented by the followingformula: ##STR7## is named17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-iodo-6,7-2',3'-indolomorphinanin accordance with the nomenclature of NTI. In accordance with thisnomenclature, specific examples of the compounds according to thepresent invention include17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-iodo-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-iodo-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-iodo-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-iodo-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-iodo-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-iodo-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-iodo-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-trifluoromethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-trifluoromethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-trifluoromethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-trifluoromethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-trifluoromethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-trifluoromethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-trifluoromethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-trifluoromethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-trifluoromethoxy-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-trifluoromethoxy-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-trifluoromethoxy-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-trifluoromethoxy-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-trifluoromethoxy-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-trifluoromethoxy-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-trifluoromethoxy-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-trifluoromethoxy-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-cyano-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-cyano-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-cyano-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-cyano-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-cyano-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-cyano-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-cyano-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-cyano-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-phenyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-phenyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-phenyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-phenyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-phenyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-phenyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-phenyl-6,7-2'1,3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-phenyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-hydroxymethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-hydroxymethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-hydroxymethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-hydroxymethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-hydroxymethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-hydroxymethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-hydroxymethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-hydroxymethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14-dihydroxy-4'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylthio-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methoxycarbonylmethyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-sulfamoyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-sulfamoyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-sulfamoyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-sulfamoyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14-dihydroxy-4'-sulfamoyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-sulfamoyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-sulfamoyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-sulfamoyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dirnethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-carbamoyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-carbamoyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-carbamoyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-carbamoyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-carbamoyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-carbamoyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-carbamoyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-carbamoyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4-(N,N-dimethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylaminomethyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylaminomethyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylaminomethyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylaminomethyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylaminomethyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14-dihydroxy-5'-(N,N-dimethylaminomethyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylaminomethyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylaminomethyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylaminomethyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylaminomethyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylaminomethyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylaminomethyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylaminomethyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylaminomethyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylaminomethyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylaminomethyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-2-(N-cyclopropylmethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-2-(N-cyclopropylmethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-2-(N-cyclopropylmethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14,-dihydroxy-7'-2-(N-cyclopropylmethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-2-(N-cyclopropylmethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-2-(N-cyclopropylmethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-2-(N-cyclopropylmethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-2-(N-cyclopropylmethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-nitro-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-nitro-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-2-(N,N-dimethylamino)ethyl!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-phenyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-2-(N,N-dimethylamino)ethyl!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-phenyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-methylthio-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-methylthio-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-methylthio-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-phenyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-phenyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-phenyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-phenyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-methylthio-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-phenyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-2-(N,N-dimethylamino)ethyl!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-phenyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-2-(N,N-dimethylamino)ethyl!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-cyano-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-cyano-6,7-2'1,3-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-cyano-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-methylthio-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-methylthio-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-methylthio-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-methylthio-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-nitro-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-nitro-6,7-2',3'-indolomorphinan,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-nitro-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-cyano-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-cyano-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-cyano-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-methylthio-6,7-2,3'3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-nitro-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-nitro-6,7-2',3'-indolomorphinan,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-nitro-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-methylthio-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-methylthio-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-methylthio-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-methylthio-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-cyano-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-cyano-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-cyano-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-nitro-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-nitro-6,7-2',3'-indolomorphinan,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-nitro-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-cyano-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-cyano-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-cyano-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-nitro-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-nitro-6,7-2',3'-indolomorphinan,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-nitro-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-methylthio-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropyimethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-methylthio-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-methylthio-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-methylthio-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-cyano-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-cyano-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-cyano-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-nitro-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-nitro-6,7-2',3'-indolomorphinan,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-nitro-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-cyano-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-cyano-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-cyano-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-methylthio-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-nitro-6,7-2',3'-indolomorphinan,17-allyl-14-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-nitro-6,7-2',3'-indolomorphinan,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-nitro-6,7-2',3'-indolomorphinanand the like.

Among the compounds represented by the formula (II), the compoundwherein R¹ is cyclopropylmethyl, R² is hydroxy, R³ is hydrogen, R⁴ ishydrogen, X is --(CH₂)₄ --bonded to 6'- and 7'-positions, that is, thecompound 2 represented by the following formula: ##STR8## is named17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole. In accordance with this nomenclature,specific examples of the compounds according to the present inventioninclude17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole, 17-allyl-3,14β-dihydroxy-4,5α-epoxy-9-ethoxycarbonyl-6,7-didehydromorphinano 6,7-b!cyclohexeno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole, 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!cycloheptenof!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole, 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!cycloocteno e!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole, 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!cyclohexeno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole, 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!cyclopenteno f!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole, 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!cycloheptenog!indole, 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!pyrido 4,3-g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-g!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-e!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-f!indole,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!pyrido4,3-g!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!pyrido2,3-g!lindole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!pyrido3,2-e!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b)pyrido2,3-f!indole,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!pyrido3,2-g!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano(6,7-b!cyclopentenof!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!pyrido 4,3-g!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-g!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-e!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-f!indole,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-g!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-blcyclohexeno e!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b)cyclohepteno f!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclooctenot e!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!pyrido 4,3-g!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-g!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-e!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-f!indole,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-g!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole, 3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano 6,7-b!cyclopentenof!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano(6,7-b!pyrido4,3-g!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-g!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-e!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-f!indole,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-g!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole, 3-acetoxy-17-allyl-4,5α-epoxy-14-hydroxy-6,7-didehydromorphinano 6,7-b)cyclohepteno f!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 4,3-g!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-g!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-e!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-f!indole,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-g!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano(6,7-b!cyclohexenoe!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 4,3-g!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-g!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-e!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-f!indole,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-g!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 4,3-g!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-g!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-e!indole,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-f!indole and14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-g!indole. Needless to say, the examples of thecompounds according to the present invention are not limited to thecompounds specifically mentioned above.

Among the compounds of the formula (I), those wherein R¹, R², R³ and R⁴represent the meanings described above, respectively, and R⁵ and R⁶independently represent hydrogen, trifluoromethyl, trifluoromethoxy,iodine, cyano, phenyl, C₁ -C₃ hydroxyalkyl, SR⁷, SO₂ R⁷, (CH₂)_(m) CO₂R⁷ (wherein m represents an integer of 0-3 and R⁷ represents C₁ -C₅alkyl), SO₂ NR⁸ R⁹, CONR⁸ R⁹, (CH₂)_(n) NR⁸ R⁹ (wherein n represents aninteger of 1-3, R⁸ and R⁹ independently represent C₁ -C₅ alkyl, C₄ -C₆cycloalkyl) or nitro (bonded to one of 4'-, 6'- and 7'-positions), thatis, the compounds represented by the formula (Ia) (excluding the casewherein R⁵ and R⁶ simultaneously represent hydrogen), and the compoundsrepresented by the formula (II) (wherein R¹, R², R³, R⁴ and X representthe same meanings as described above, respectively) can be obtained bythe following method: ##STR9##

CHART 1

That is, these compounds can easily be obtained by reacting the compoundrepresented by the formula (III) with the phenylhydrazine derivativerepresented by the formula (IV) or (V) (wherein R⁴ and X represent thesame meanings as described above, R⁵ and R⁶ independently representhydrogen, trifluoromethyl, trifluoromethoxy, iodine, cyano, phenyl, C₁-C₃ hydroxyalkyl, SR⁷, SO₂ R⁷, (CH₂)_(m) CO₂ R⁷ (wherein m represents aninteger of 0-3, R⁷ represents C₁ -C₅ alkyl), SO₂ NR⁸ R⁹, CONR⁸ R⁹,(CH₂)_(n) NR⁸ R⁹ (wherein n represents an integer of 1-3, R⁸ and R⁹independently represent hydrogen, C₁ -C₅ alkyl or C₄ -C₆cycloalkylalkyl), or nitro (bonded to 2- or 3-position), with theproviso that R⁵ and R⁶ are not simultaneously hydrogen) in a solvent inthe presence of an acid catalyst. Examples of the solvent includealcoholic solvents such as methanol and ethanol; aliphatic acid solventssuch as acetic acid and propionic acid; and dipolar aprotic solventssuch as DMF and DMSO. Among these, alcoholic solvents and aliphatic acidsolvents are preferred, and ethanol and acetic acid are best preferred.Examples of the acid catalyst include inorganic acids such ashydrochloric acid, sulfuric acid, nitric acid and phosphoric acid; andorganic acids such as methanesulfonic acid, p-toluenesulfonic acid,acetic acid, formic acid and propionic acid. Among these, hydrochloricacid, sulfuric acid and methanesulfonic acid are preferred. The reactionmay be carried out at 0°-300° C., preferably 25°-150° C., morepreferably 60°-120° C.

Among the compounds represented by the formula (I), the compoundswherein R¹, R² and R⁴ represent the same meanings as described above, R³is hydrogen, R⁵ is (CH₂)_(n) NR⁸ R⁹ (wherein n=1, R⁸ and R⁹ representthe same meanings described above), and R⁶ is hydrogen, that is, thecompounds represented by the formula (Id) can also be obtained from thecompounds of the formula (I) wherein R¹, R² and R⁴ represent the samemeanings as described above, R³ is hydrogen, R⁵ is CONR⁸ R⁹ (wherein R⁸and R⁹ represent the same meanings described above), and R6 is hydrogen,that is, the compounds represented by the formula (Ib). ##STR10##

CHART 2

The first step is the step for protecting the phenolic hydroxyl groupwith tert-butyldimethylsilyl group in the presence of a base. As thebase, triethylamine, diisopropylethylamine, imidazole and the like maybe employed and satisfactory results are usually obtained by usingimidazole. As the solvent, halogen-substituted solvents such asmethylene chloride and chloroform, and DMF and the like may be employed.Among these, DMF is preferred. The reaction temperature range may bebetween -50° and 150° C. and satisfactory results are usually obtainedat 0°-30° C. The second step is the step for reducing amide to amine andfor removing the protective group. As the reducing agent, lithiumaluminum hydride, diborane, diisobutylaluminum hydride and the like maybe employed, and diborane is best preferred. As the solvent, ethersolvents such as ether, THF, DME and dioxane are preferred andsatisfactory results are usually obtained by using THF. The reaction canbe carried out at -50°-150° C., and especially good results are obtainedat 50°-100° C. The removal of the protective group is carried outsimultaneously when an acid is added for decomposition of the reducingreaction. The reaction is carried out by direct addition of an acid tothe reaction solution. Examples of the acid used here includehydrochloric acid, sulfuric acid, nitric acid and the like, andhydrochloric acid is best preferred. The reaction can be carried out at0°-150° C., and especially good results are obtained at 50°-100° C.

Among the compounds of the formula (I), those wherein R¹, R², R³ and R⁴represent the same meanings as described above, R⁵ representsisothiocyanato (bonded to one of 4'-, 6'- and 7'-positions), and R⁶ ishydrogen, that is, the compounds represented by the formula (Ig) can beobtained through two steps from the compounds of the formula (I) whereinR¹, R², R³ and R⁴ represent the same meanings as described above, R⁵ isnitro (bonded to one of 4'-, 6'- and 7'-positions), and R⁶ is hydrogen,that is, the compounds represented by the formula (Ie). ##STR11##

CHART 3

The first step is the step for reducing the nitro group to amino group.Methods for the reduction include a method wherein hydrogenation iscarried out by using a catalyst such as palladium or platinum; a methodwherein reduction is carried out by using a metal hydride such aslithium aluminum hydride; a method in which a metal such as iron, tin,zinc or the like and an acid are used; and a method in which thereduction is carried out by using stannous chloride. Satisfactoryresults are obtained by using stannous chloride. As the solvent,alcohols solvents such as methanol and ethanol are preferred, andethanol is especially preferred. The reaction may be carried out at0°-80° C., preferably 50°-80° C. The second step is the step forreaction of the amine with thiophosgene to convert the amine toisothiocyanate. As the solvent, two-phase systems betweenhalogen-substituted solvents such as chloroform and methylene chloride,and aqueous sodium hydrogen carbonate solution or dilute hydrochloricacid are preferred, and chloroform-dilute hydrochloric acid isespecially preferred. The reaction may be carried out at -50°-60° C.,preferably 0°-30° C.

As the phenylhydrazine derivatives represented by the formula (IV)wherein R⁴ represents the same meanings as described above, R⁵ and R⁶independently represent hydrogen, iodine, trifluoromethyl,trifluoromethoxy, cyano, phenyl, C₁ -C₃ hydroxyalkyl, SR⁷, SO₂ R⁷,(CH₂)_(m) CO₂ R⁷ (wherein m represents an integer of 0-3, R⁷ representsC₁ -C₅ alkyl), SO₂ NR⁸ R⁹, CONR⁸ R⁹, (CH₂)_(n) NR⁸ R⁹ (wherein nrepresents an integer of 1-3, R⁸ and R⁹ independently representshydrogen, C₁ -C₅ alkyl, or C₄ -C₆ cycloalkylalkyl) or nitro (bonded to2- or 3-position), with the proviso that R⁵ and R⁶ are notsimultaneously hydrogen!, commercially available compounds orsynthesized products are used. The derivative (IVa) wherein R⁴ ishydrogen is derived from a nitrobenzene derivative (VI) or an anilinederivative (VII) through the route shown in Chart 4. ##STR12##

CHART 4

The first step is the step for reduction of nitro group to amino group.Similar to the first step in Chart 2, various methods may be employed.Satisfactory results are obtained by employing hydrogenation or themethod using stannous chloride. As the catalyst for hydrogenation,platinum oxide, palladium-carbon or the like can be employed and thereaction normally proceeds under 1 atm of hydrogen atmosphere. As thesolvent, alcoholic solvents such as methanol and ethanol are preferredand methanol is especially preferred. The reaction may be carried out at-20°-60° C., preferably 0°-30° C. The conditions of the reactionemploying stannous chloride are the same as the first step in Chart 2.The second step is the step for reaction of the product with nitrite ionunder acidic condition for conversion of the compound to diazonium ionand for reduction of the resultant to hydrazine. As the diazotizationagent, sodium nitrite, potassium nitrite and the like may be employed,and satisfactory results are usually obtained by using sodium nitrite.The reaction is carried out using concentrated hydrochloric acid as thesolvent. The reaction may be carried out at -30°-100° C., preferably-10°-30° C., and is usually carried out at 0° C. The reduction may becarried out using stannous chloride, tin, iron, zinc or the like in thepresence of an acid, and satisfactory results are usually obtained byusing stannous chloride. As the solvent, concentrated hydrochloric acidis used. The reaction temperature is preferably -30°-50° C. and goodresults are usually obtained at 0° C.

Among the compounds represented by the formula (V), those wherein R⁴ ishydrogen (i.e., Compound Va; wherein X represents the same meanings asdescribed above) can also be obtained from (VIII) or (IX) similarly.

The phenylhydrazine derivative (IVf) wherein R⁴ represents the samemeanings as described above, R⁵ is CONR⁸ R⁹ (wherein R⁸ and R⁹ representthe same meanings as described above), and R6 is hydrogen can also besynthesized from the phenylhydrazine derivative (IVb) wherein R⁴represents the same meanings as described above, R⁵ is CO₂ R⁷ (whereinR⁷ represents the same meanings as described above), and R⁶ is hydrogen,by the method shown in Chart 5. ##STR13##

CHART 5

The first step is the step for protection of hydrazine withtert-butoxycarbonyl group. For this reaction, di-tert-butylcarbonate isemployed. As the solvents, mixed solvents of an organic solvent-aqueoussolvent are employed. As the organic solvent, halogen-substitutedsolvents such as chloroform and methylene chloride are preferred, and asthe aqueous solvent, aqueous sodium hydrogen carbonate solution, aqueouspotassium carbonate solution, aqueous sodium hydroxide solution, andaqueous potassium hydroxide solution are preferred. Mixed solvent ofchloroform--aqueous sodium hydrogen carbonate solution is especiallypreferred, although the solvent is not restricted thereto. The reactionmay be carried out at 0°-150° C. and satisfactory results are usuallyobtained at 50°-100° C. The second step is the step for hydrolyzing theester under basic condition. As the base, sodium hydroxide, potassiumhydroxide or the like may be employed. As the solvent, mixed solventsbetween an ether solvent such as dioxane or THF and water are preferablyemployed. The reaction may be carried out at 0°-150° C., andsatisfactory results are obtained at 50°-100° C. The third step is thestep for condensing the carboxylic acid with amine to form amide. As thecondensing agent, DCC, 3-(3-dimethylaminopropyl)-1-ethylcarbodiimidehydrochloric acid salt and the like are employed. In view of the ease ofpost-treatment, 3-(3-dimethylaminopropyl)-1-ethylcarbodiimidehydrochloric acid salt is preferred. As the solvent, halogen-substitutedsolvents such as chloroform, methylene chloride and 1,2-dichloroethaneare preferred. The reaction may be carried out at 0°-150° C., preferablyat 20°-80° C. The fourth step is the step for removing the protectivegroup of hydrazine under acidic condition. As the acid, hydrochloricacid, sulfuric acid, nitric acid and the like may be employed, andhydrochloric acid is preferred. As the solvent, alcoholic solvents suchas ethanol and methanol, ether solvents such as THF and dioxane, andethyl acetate and the like are preferred, and satisfactory results areusually obtained by using ethyl acetate. The reaction may be carried outat -20°-100° C., preferably at 0°-30° C.

When the compound of the present invention is clinically applied as animmunosuppressing agent, brain cell-protecting agent, antiallergic agentand anti-inflammatory agent, the free base or the acid addition saltthereof per se may be administered, or the active compound may beadministered after mixing with an appropriate excipient such as astabilizer, buffering agent, diluent, isotonic agent, antiseptic or thelike. The compound may be formulated into various forms such asinjection solutions, sublingual tablets, capsules, suppositories,formulations for oral administration and the like. The dose ofadministration is appropriately determined based on the object ofadministration, route of administration and conditions of the patient.In case of injection, 0.0001-1 g/day of the active compound isadministered, and in case of oral administration, 0.001-10 g/day of theactive compound is administered. The content of the compound of thepresent invention in a pharmaceutical formulation may be 0.05-99%. Incase of injection solutions, the content may be 0.5-20%, and in case offormulations for oral administration, the content may be 0.1-50%.

EXAMPLES

The present invention will now be described by way of examples andreference examples. However, the present invention is not limited to thefollowing examples.

Reference Example 1

N,N-dimethyl-2-(4-nitrophenyl)ethylamine

To 4.17 g of 2-(4-nitrophenyl)ethylamine (salt-free compound obtained byneutralization of commercially available hydrochloric acid salt), 1.1 mlof water was added. After cooling the mixture to 0° C., 4.8 ml of formicacid and 4.7 ml of aqueous 35% formalin solution were added to themixture, and the resulting mixture was heated to reflux for 1 hour. Theresulting mixture was cooled to 0° C. and 55 ml of 2N aqueous sodiumhydroxide solution was added to make the mixture basic. The resultantwas subjected to salting out and the resultant was extracted with ether(2×60 ml). The organic layers were combined, dried and concentrated,thereby obtaining 4.91 g of unpurified captioned compound.

NMR (90 MHz, CDCl3); δ 2.30 (6H, s), 2.43-2.67 (2H, m), 2.79-3.07 (2H,m), 7.38 (2H, d, J=9 Hz), 8.16 (2H, d, J=9 Hz).

By using 2-(3-nitrophenyl)ethylamine, 2-(2-nitrophenyl)ethylamine,4-nitrobenzylamine, 3-nitrobenzylamine or 2-nitrobenzylamine in place of2-(4-nitrophenyl)ethylamine, N,N-dimethyl-2-(3-nitrophenyl)ethylamine,N,N-dimethyl-2-(2-nitrophenyl)ethylamine,N,N-dimethyl-4-nitrobenzylamine, N,N-dimethyl-3-nitrobenzylamine andN,N-dimethyl-2-nitrobenzylamine are obtained, respectively.

Reference Example 2

4- 2-(dimethylamino)ethyl!aniline

The 4.91 g of unpurified N,N-dimethyl-2-(4-nitrophenyl)ethylamineobtained in Reference Example 1 was dissolved in 70 ml of methanol and96.1 mg of platinum oxide was added to the solution, followed bystirring the resulting mixture under hydrogen atmosphere (1 atm) at roomtemperature. After one hour from the beginning of the stirring, another49.3 mg of platinum oxide was added and the mixture was stirred totally4 hours. The reaction mixture was filtered through Celite, and thefiltration residue was washed with methanol. The filtrate and thewashing were combined and concentrated to obtain 4.11 g of unpurifiedcaptioned compound.

NMR (90 MHz, CDCl3); δ 2.28 (6H, s), 2.37-2.92 (4H, m), 3.55 (2H, br s,NH2), 6.63 (2H, d, J=9 Hz), 7.01 (2H, d, J=9 Hz).

Reference Example 3

4-dimethylaminomethylaniline

In 30 ml of ethanol, 2.93 g of N,N-dimethyl-4-nitrobenzylamine wasdissolved, and 18.3 g of tin(II) chloride dihydrate was added to thesolution, followed by stirring the resulting solution at 70° C. for 40minutes. The reaction mixture was cooled to 0° C., and 100 ml of 2Naqueous sodium hydroxide solution was added to make the mixture basic.The resulting mixture was extracted with ethyl acetate (2×100 ml) andthe organic layers were combined, dried and concentrated to obtain 2.46g of unpurified captioned compound.

NMR (90 MHz, CDCl3); δ 2.20 (6H, s), 3.39 (2H, br s), 3.62 (2H, br s,NH2), 6.63 (2H, d, J=8.5 Hz), 7.08 (2H, d, J=8.5 Hz).

By using N,N-dimethyl-3-nitrobenzylamine orN,N-dimethyl-2-nitrobenzylamine in place ofN,N-dimethyl-4-nitrobenzylamine, 3-dimethylaminomethylaniline and2-dimethylaminomethylaniline are obtained, respectively.

Reference Example 4

4- 2-(dimethylamino)ethyl!phenylhydrazine

In 26 ml of concentrated hydrochloric acid, 2.18 g of the unpurified 4-2-(dimethylamino)ethyl!aniline obtained in Reference Example 2 wasdissolved at 0° C., and a solution containing 1.92 g of sodium nitritein 8 ml of water was added dropwise, followed by stirring the resultingmixture at 0° C. for 1 hour. The resulting mixture was added to asolution containing 12.7 g of tin(II) chloride dihydrate in 5 ml ofconcentrated hydrochloric acid at 0° C. and the resulting mixture wasstirred for 1 hour. To the reaction mixture, about 17 g of sodiumhydroxide was added at 0° C. to make the mixture basic and the resultantwas extracted with chloroform (2×50 ml). The organic layers werecombined, dried and concentrated to obtain 1.90 g of an oily product.The obtained oily product was purified by column chromatography silicagel; chloroform saturated with ammonia! to obtain 1.10 g of thecaptioned compound (yield 46%, 3 steps).

NMR (90 MHz, CDCl3); δ 2.28 (6H, s), 2.38-2.83 (4H, m), 3.38 (2H, br s,NH2), 5.10 (1H, br s, NH), 6.74 (2H, d, J=9 Hz), 7.08 (2H, d, J=9 Hz).

In accordance with Reference Examples 2 and 4, by usingN,N-dimethyl-2-(3-nitrophenyl)ethylamine,N,N-dimethyl-2-(2-nitrophenyl)ethylamine, 3-nitrophenethyl alcohol,N-cyclopropylmethyl-4-nitrobenzenesulfonamide,N-cyclopropylmethyl-3-nitrobenzenesulfonamide,N-cyclopropylmethyl-2-nitrobenzenesulfonamide, ethyl4-nitrophenylacetate, ethyl 3-nitrophenylacetate, ethyl2-nitrophenylacetate, N,N-dimethyl-4-nitrobenzenesulfonamide,N,N-dimethyl-3-nitrobenzenesulfonamide,N,N-dimethyl-2-nitrobenzenesulfonamide or 3-nitrobenzenesulfonamide inplace of N,N-dimethyl-2-(4-nitrophenyl)ethylamine, 3-2-(dimethylamino)ethyl!phenylhydrazine, 2-2-(dimethylamino)ethyl!phenylhydrazine,3-(2-hydroxyethyl)phenylhydrazine,4-(N-cyclopropylmethylsulfamoyl)phenylhydrazine,3-(N-cyclopropylmethylsulfamoyl)phenylhydrazine,2-(N-cyclopropylmethylsulfamoyl)phenylhydrazine,4-ethoxycarbonylmethylphenylhydrazine,3-ethoxycarbonylmethylphenylhydrazine,2-ethoxycarbonylmethylphenylhydrazine,4-(N,N-dimethylsulfamoyl)phenylhydrazine,3-(N,N-dimethylsulfamoyl)phenylhydrazine,2-(N,N-dimethylsulfamoyl)phenylhydrazine and 3-sulfamoylphenylhydrazineare obtained, respectively.

In accordance with Reference Example 4, by using4-dimethylaminomethylaniline, 3-dimethylaminomethylaniline,2-dimethylaminomethylaniline, 4-aminophenethyl alcohol, 2-aminophenethylalcohol, 2-aminobenzenesulfonamide, 4-aminobenzonitrile,3-aminobenzonitrile, 4-aminobiphenyl, 3-aminobiphenyl, 2-aminobiphenyl,3-trifluoromethoxyaniline, 2-trifluoromethoxyaniline, 4-iodoaniline,3-iodoaniline, 2-iodoaniline, ethyl 4-aminobenzoate, ethyl3-aminobenzoate, ethyl 2-aminobenzoate, methyl 4-aminobenzoate, methyl3-aminobenzoate, methyl 2-aminobenzoate,1-amino-5,6,7,8-tetrahydronaphthalene,2-amino-5,6,7,8-tetrahydronaphthalene, 5-aminoisoquinoline,5-aminoquinoline, 6-aminoquinoline, 8-aminoquinoline, 4-aminoindan,5-aminoindan, 1-amino-6,7,8,9-tetrahydro-5H-benzocycloheptene,2-amino-6,7,8,9-tetrahydro-5H-benzocycloheptene,1-amino-5,6,7,8,9,10-hexahydrobenzocyclooctene,2-amino-5,6,7,8,9,10-hexahydrobenzocyclooctene,1-amino-5-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-amino-6-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-amino-7-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-amino-8-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-amino-5-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-amino-6-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-amino-7-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-amino-8-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-amino-5-sulfamoyl-5,6,7,8-tetrahydronaphthalene,1-amino-6-sulfamoyl-5,6,7,8-tetrahydronaphthalene,1-amino-7-sulfamoyl-5,6,7,8-tetrahydronaphthalene or1-amino-8-sulfamoyl-5,6,7,8-tetrahydronaphthalene in place of 4-2-(dimethylamino)ethyl!aniline,4-(N,N-dimethylaminomethyl)phenylhydrazine,3-(N,N-dimethylaminomethyl)phenylhydrazine,2-(N,N-dimethylaminomethyl)phenylhydrazine,4-(2-hydroxyethyl)phenylhydrazine, 2-(2-hydroxyethyl)phenylhydrazine,2-sulfamoylphenylhydrazine, 4-cyanophenylhydrazine,3-cyanophenylhydrazine, 4-phenylphenylhydrazine,3-phenylphenylhydrazine, 2-phenylphenylhydrazine,3-trifluoromethoxyphenylhydrazine, 2-trifluoromethoxyphenylhydrazine,4-iodophenylhydrazine, 3-iodophenylhydrazine, 2-iodophenylhydrazine,4-ethoxycarbonylphenylhydrazine, 3-ethoxycarbonylphenylhydrazine,2-ethoxycarbonylphenylhydrazine, 4-methoxycarbonylphenylhydrazine,3-methoxycarbonylphenylhydrazine, 2-methoxycarbonylphenylhydrazine,1-hydrazino-5,6,7,8-tetrahydronaphthalene,2-hydrazino-5,6,7,8-tetrahydronaphthalene, 5-hydrazinoisoquinoline,5-hydrazinoquinoline, 6-hydrazinoquinoline, 8-hydrazinoquinoline,4-hydrazinoindan, 5-hydrazinoindan,1-hydrazino-6,7,8,9-tetrahydro-5H-benzocycloheptene,2-hydrazino-6,7,8,9-tetrahydro-5H-benzocycloheptene,1-hydrazino-5,6,7,8,9,10-hexahydrobenzocyclooctene,2-hydrazino-5,6,7,8,9,10-hexahydrobenzocyclooctene,1-hydrazino-5-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-6-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-7-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-8-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-5-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-6-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-7-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-8-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-5-sulfamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-6-sulfamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-7-sulfamoyl-5,6,7,8-tetrahydronaphthalene, and1-hydrazino-8-sulfamoyl-5,6,7,8-tetrahydronaphthalene are obtained,respectively.

Reference Example 5

1-tert-butoxycarbonyl-2-(3-methoxycarbonylphenyl)hydrazine

In 40 ml of chloroform, 4.00 g of 3-methoxycarbonylphenylhydrazinemethanesulfonic acid salt was dissolved. To this solution, aqueoussodium hydrogen carbonate (1.31 g/30 ml) was added and then 3.6 ml ofdi-tert-butyldicarbonate was added to the mixture, followed by heatingthe resulting mixture to reflux for one hour. After leaving the mixtureto cool to room temperature, the mixture was separated and the aqueouslayer was extracted with chloroform (2×20 ml). The organic layers werecombined, dried and concentrated to obtain 4.68 g of unpurifiedcaptioned compound.

NMR (90 MHz, CDCl3); δ 1.44 (9H, s), 3.90 (3H, s), 5.85 (1H, br s , NH),6.44 (1H, m, NH), 7.00 (1H, ddd, J=8, 3, 2 Hz), 7.30 (1H, ddd, J=8, 8, 1Hz), 7.47-7.63 (2H, m).

Reference Example 6

3-(2-tert-butoxycarbonylhydrazino)benzoic acid

The 4.68 g of unpurified1-tert-butoxycarbonyl-2-(3-methoxycarbonylphenyl)hydrazine was dissolvedin 75 ml of 1,4-dioxane, and 25 ml of aqueous 3N potassium hydroxidesolution was added to the solution, followed by heating the mixture toreflux for one hour. The reaction mixture was cooled to 0° C., and about25 ml of 3N hydrochloric acid was added to make the reaction mixtureacidic. The mixture was subjected to salting out and the resultant wasextracted with ethyl acetate (2×50 ml). The organic layers werecombined, dried and concentrated to obtain 4.40 g of unpurifiedcaptioned compound.

NMR (90 MHz, CDCl3); δ 1.47 (9H, s), 5.5-6.4 (2H, br s, OH, NH), 6.60(1H, m, NH), 7.05 (1H, m), 7.32 (1H, br dd, J=8, 8 Hz), 7.50-7.70 (2H,m).

Reference Example 7

1-tert-butoxycarbonyl-2-3-(N-cyclopropylmethylcarbamoyl)phenyl!hydrazine

The 4.40 g of unpurified 3-(2-tert-butoxycarbonylhydrazino)benzoic acidwas dissolved in 80 ml of dichloromethane. To this mixture, 1.78 g ofcyclopropylmethylamine and 3.45 g of3-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloric acid saltwere added and the resulting mixture was heated to reflux for 2 hours.After leaving the reaction mixture to cool to room temperature, themixture was sequentially washed with 50 ml of water, 50 ml of 1Nhydrochloric acid and then 50 ml of aqueous saturated sodium hydrogencarbonate solution, dried and concentrated to obtain 3.42 g of crudecrystals. The crude crystals were recrystallized twice from ethylacetate-hexane to obtain 1.29 g (yield 40%, three steps) of thecaptioned compound.

NMR (90 MHz, CDCl3); δ 0.29 (2H, m), 0.58 (2H, m), 1.15 (1H, m), 1.46(9H, s), 3.28 (2H, dd, J=7.0, 6.5 Hz), 5.58 (1H, m, NH), 6.21 (1H, m,NH), 6.47 (1H, br s, NH), 6.95 (1H, m), 7.15-7.38 (3H, m).

Reference Example 8

3-(N-cyclopropylmethylcarbamoyl)phenylhydrazine

In 5 ml of ethyl acetate, 1.92 g of 1-tert-butoxycarbonyl-2-3-(N-cyclopropylmethylcarbamoyl)phenyl!hydrazine was dissolved and about12 ml of 2N hydrochloric acid/ethyl acetate solution was added to thesolution. The resulting suspension was stirred at room temperature for 4hours. To the reaction mixture, 15 ml of aqueous 2N ammonia solution wasadded and the resultant was extracted with 20 ml of ethyl acetate. Theextract was dried and concentrated to obtain 1.28 g of crude crystals.The crude crystals were recrystallized from ethyl acetate-hexane toobtain 1.20 g (yield 93%) of the captioned compound.

NMR (90 MHz, CDCl3); δ 0.30 (2H, m), 0.59 (2H, m), 1.15 (1H, m), 1.7-4.3(3H, br s, NH2, NH), 3.31 (2H, dd, J=7.0, 5.5 Hz), 6.25 (1H, m, NH),6.93 (1H, m), 7.05-7.38 (3H, m).

In accordance with Reference Examples 5-8, by using4-methoxycarbonylphenylhydrazine or 2-methoxyphenylhydrazine in place of3-methoxycarbonylphenylhydrazine,4-(N-cyclopropylmethylcarbamoyl)phenylhydrazine and2-(N-cyclopropylmethylcarbamoyl)phenylhydrazine are obtained,respectively.

Example 1

17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-iodo-6,7-2',3'-indolomorphinan 1 ##STR14##

In 15 ml of ethanol, 950 mg of naltrexone hydrochloric acid salt and 590mg of 4-iodophenylhydrazine were dissolved and then 0.36 ml ofmethanesulfonic acid was added to the solution, followed by heating theresulting mixture to reflux for 3 hours. After cooling the reactionmixture to room temperature, 20 ml of aqueous saturated sodium hydrogencarbonate solution was added while cooling the mixture in iced water toneutralize the mixture and the resultant was extracted three times with30 ml of chloroform. The organic layers were combined and washed with 15ml of aqueous saturated saline. The resultant was dried and concentratedand the obtained residue was purified by column chromatography silicagel; chloroform:methanol:28% aqueous ammonia solution (97:3:0.3)!. Theobtained powder was suspended in methanol and methanesulfonic acid wasadded to convert the compound to methanesulfonic acid salt. Theresultant was purified by column chromatography SEPHADEX LH-20;methanol! to obtain 492 mg of methanesulfonic acid salt of the captionedcompound (yield 31%).

1 methanesulfonic acid salt

mp.:220° C. (decomposed); NMR (400 MHz, DMSO-d6); δ 0.44 (1H, m), 0.49(1H, m), 0.63 (1H, m), 0.72(1H, m), 1.10 (1H, m), 1.82 (1H, br d, J=11.7Hz), 2.29 (3H, s), 2.50-2.63 (2H, m), 2.70 (1H, m), 2.91 (1H, d, J=16.1Hz), 2.92 (1H, m), 3.11 (1H, m), 3.22 (1H, dd, J=19.5, 6.8 Hz),3.36-3.47 (2H, m), 4.04, (1H, d, J=6.4 Hz), 5.68 (1H, s), 6.34 (1H, s),6.60 (1H, d, J=8.3 Hz), 6.64 (1H, d, J=8.3 Hz), 7.22 (1H, d, J=8.3 Hz),7.37 (1H, dd, 8.3, 1.7 Hz), 7.70 (1H, d, J=1.7 Hz), 8.94 (1H, br s),9.25 (1H, s), 11.55 (1H, s). IR (KBr); ν 3350, 3220, 1510, 1195, 1048cm⁻¹. Mass (FAB); m/z 541 ((M+H))⁺. Elementary Analysis: C₂₆ H₂₅ N₂ O₃I.CH₃ SO₃ H.o.0.4H₂ O; Calcd.:C, 50.38; H, 4.67; N, 4.35; I, 19.71; S,4.98. Found:C, 50.39; H, 4.91; N, 4.35; I, 19.76; S, 4.92.

By using 4-ethoxycarbonylphenylhydrazine,4-trifluoromethoxyphenylhydrazine, 4-sulfamoylphenylhydrazine,4-methylsulfonylphenylhydrazine,4-(N-cyclopropylmethylcarbamoyl)phenylhydrazine, 4-cyanophenylhydrazine,4- 2-(N,N-dimethylamino)ethyl!phenylhydrazine,4-(N,N-dimethylamino)methylphenylhydrazine, 4-phenylphenylhydrazine,4-methylthiophenylhydrazine,4-(N-cyclopropylmethylsulfamoyl)phenylhydrazine,4-(N,N-dimethylsulfamoyl)phenylhydrazine,4-(2-hydroxyethyl)phenylhydrazine,4-ethoxycarbonylmethylphenylhydrazine, 1-methyl-1- 4-2-(N,N-dimethylamino)ethyl!phenyl!hydrazine, 1-methyl-1-4-(N,N-dimethylamino)methylphenyl!hydrazine,1-methyl-1-(4-phenylphenyl)hydrazine or1-methyl-1-(4-methylthiophenyl)hydrazine in place of4-iodophenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan3,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-trifluoromethoxy-6,7-2',3'-indolomorphinan4,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-sulfamoyl-6,7-2',3'-indolomorphinan5,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan6,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan7,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-cyano-6,7-2',3'-indolomorphinan8, 17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-2-(N,N-dimethylamino)ethyl!-6,7-2',3'-indolomorphinan 9,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan10,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-phenyl-6,7-2',3'-indolomorphinan11,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylthio-6,7-2',3'-indolomorphinan12,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan13,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan14, 17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan 15,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan16,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-2-(N,N-dimethylamino)ethyl!-6,7-2',3'-indolomorphinan 17,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan18,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-phenyl-6,7-2',3'-indolomorphinan19 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-methylthio-6,7-2',3'-indolomorphinan20 are obtained, respectively.

By using naloxone hydrochloric acid salt in place of naltrexonehydrochloric acid salt, and by using 4-iodophenylhydrazine,4-ethoxycarbonylphenylhydrazine, 4-trifluoromethoxyphenylhydrazine,4-sulfamoylphenylhydrazine, 4-methylsulfonylphenylhydrazine,4-(N-cyclopropylmethylcarbamoyl)phenylhydrazine, 4-cyanophenylhydrazine,4- 2-(N,N-dimethylamino)ethyl!phenylhydrazine,4-(N,N-dimethylamino)methylphenylhydrazine, 4-phenylphenylhydrazine,4-methylthiophenylhydrazine,4-(N-cyclopropylmethylsulfamoyl)phenylhydrazine,4-(N,N-dimethylsulfamoyl)phenylhydrazine,4-(2-hydroxyethyl)phenylhydrazine,4-ethoxycarbonylmethylphenylhydrazine, 1-methyl-1- 4-2-(N,N-dimethylamino)ethyl!phenyl!hydrazine, 1-methyl-1-4-(N,N-dimethylamino)methylphenyl!hydrazine,1-methyl-1-(4-phenylphenyl)hydrazine or1-methyl-1-(4-methylthiophenyl)hydrazine as the phenylhydrazinederivative,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-iodo-6,7-2',3'-indolomorphinan21,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan22,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-trifluoromethoxy-6,7-2',3'-indolomorphinan23,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-sulfamoyl-6,7-21,31-indolomorphinan24,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan25,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3,-indolomorphinan26,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-cyano-6,7-2',3'-indolomorphinan27, 17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-2-(N,N-dimethylamino)ethyl!-6,7-2',3'-indolomorphinan 28,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan29,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-phenyl-6,7-2',3'-indolomorphinan30,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylthio-6,7-2',3'-indolomorphinan31,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan32,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan33,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan34,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan35, 17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-2-(N,N-dimethylamino)ethyl!-6,7-2',3'-indolomorphinan 36,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan37,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-phenyl-6,7-2',3'-indolomorphinan38 and17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-5'-methylthio-6,7-2',3'-indolomorphinan39 are obtained, respectively.

3 methanesulfonic acid salt (yield 52%)

mp.>220° C. (decomposed). NMR (400 MHz, DMSO-d6); δ 0.44 (1H, m), 0.50(1H, m), 0.63 (1H, m), 0.74 (1H, m), 1.14 (1H, m), 1.31 (3H, t, J=7.0Hz), 1.83 (1H, m), 2.31 (3H, s), 2.60 (1H, d, J=16.1 Hz), 2.61 (1H, m),2.72 (1H, m), 2.95 (1H, m), 3.02 (1H, d, J=16.1 Hz), 3.12 (1H, m), 3.26(1H, dd, J=20.0, 6.8 Hz), 3.39 (1H, m), 3.45 (1H, d, J=20.0 Hz), 4.09(1H, br d, J=6.4 Hz), 4.27 (2H, q, J=7.0 Hz), 5.71 (1H, s), 6.35 (1H, brs, OH), 6.61 (1H, d, J=8.3 Hz), 6.64 (1H, d, J=8.3 Hz), 7.44 (1H, d,J=8.8 Hz), 7.75 (1H, dd, J=8.8, 1.5 Hz), 8.07 (1H, br s), 8.95 (1H, m,NH⁺), 9.26 (1H, br s, OH), 11.80 (1H, s, NH). IR (KBr) ν 3400, 1702,1638, 1626, 1464, 1330, 1311, 1249, 1207, 1172, 1116, 1046, 870, 774cm⁻¹. Mass (FAB); m/z 497 ((M+H)⁺). Elementary Analysis: C₂₉ H₃₀ N₂O₅.CH₃ SO₃ H.0.7H₂ O; Calcd.:C, 60.53; H, 5.99; N, 4.71; S, 5.36.Found:C, 60.53; H, 6.20; N, 4.65; S, 5.57.

4 hydrochloric acid salt (yield 57%)

mp.:235° C. (decomposed); NMR (500 MHz, DMSO-d6); δ 0.44 (1H, m), 0.51(1H, m), 0.63 (1H, m), 0.73(1H, m), 1.11 (1H, m), 1.82 (1H, br d, J=11.6Hz), 2.54 (1H, d,. J=15.9 Hz), 2.62 (1H, td, J=12.8, 4.3 Hz), 2.71 (1H,m), 2.97 (1H, m) 2.99 (1H, d, J=15.9 Hz), 3.12 (1H, m), 3.24 (1H, dd,J=19.5, 6.7 Hz), 3.36 (1H, m), 3.44 (1H, d, J=19.5 Hz),4.11, (1H, d,J=6.1 Hz), 5.70 (1H, s), 6.41 (1H, s), 6.60 (1H, d, J=8.3 Hz), 6.66 (1H,d, J=8.3 Hz), 7.08 (1H, d, J=8.5 Hz), 7.30 (1H, s), 7.44 (1H, d, J=8.5Hz), 8.99(1H, br s), 9.27 (1H, s), 11.66 (1H, s). IR (KBr) ν 3270, 1508,1460, 1267, 1205, 1152, 1116, 868, 801 cm⁻¹ Mass (FAB); m/z 499((M+H)⁺). Elementary Analysis: C₂₇ H₂₅ N₂ O₄ F.HCl; Calcd.:C, 60.62; H,4.90; N, 5.24; F, 10.65; Cl, 6.63. Found:C, 60.66; H, 5.06; N, 5.37; F,10.40; Cl, 6.44.

5 methanesulfonic acid salt (yield 68%)

mp.:184° C. (decomposed); NMR (500 MHz, DMSO-d6); δ 0.44 (1H, m), 0.50(1H, m), 0.64 (1H, m), 0.74(1H, m), 1.10 (1H, m), 1.83 (1H, br d, J=11.0Hz), 2.30 (3H, s) 2.59 (1H, d,. J=15.9 Hz), 2.61 (1H, m), 2.72 (1H, m),2.95 (1H, m) 2.98 (1H, d, J=15.9 Hz), 3.13 (1H, m), 3.28 (1H, m), 3.39(1H,m), 3.44 (1H, d, J=19.5 Hz), 4.09 (1H, d, J=6.7 Hz), 5.72 (1H, s),6.35 (1H, s), 6.60 (1H, d, J=7.9 Hz), 6.64 (1H, d, J=7.9 Hz), 7.10 (2H,s), 7.50 (1H, d, J=8.5 Hz), 7.59 (1H, dd, J=8.5, 1.8 Hz), 7.86 (1H, d,J=1.8 Hz), 8.93(1H, br s), 9.22 (1H, s), 11.79 (1H, s). IR (KBr) ν 3190,1626, 1508, 1462, 1328, 1195, 1154, 1046, 774, 625 cm⁻¹. Mass (FAB); m/z494 ((M+H)⁺). Elementary Analysis: C₂₆ H₂₇ N₃ O₅ S.CH₃ SO₃ H.0.5H₂ O;Calcd.:C, 54.17; H, 5.39; N, 7.02; S, 10.71. Found:C, 54.50; H, 5.51; N,6.84; S, 10.39.

6 methanesulfonic acid salt (yield 75%)

mp.:205° C. (decomposed); NMR (400 MHz, DMSO-d6); δ 0.44 (1H, m), 0.50(1H, m), 0.63 (1H, m), 0.73(1H, m), 1.11 (1H, m), 1.84 (1H, br d, J=11.2Hz), 2.30 (3H, s) 2.60 (1H, d,. J=16.1 Hz), 2.63 (1H, m), 2.72 (1H, m),2.95 (1H, m) 3.03 (1H, d, J=16.1 Hz), 3.10 (3H, s) 3.12 (1H, m), 3.24(1H, m), 3.38 (1H,m), 3.46 (1H, d, J=20.0 Hz), 4.08 (1H, d, J=6.3 Hz),5.74 (1H, s), 6.38 (1H, s), 6.61 (1H,d, J=7.8 Hz), 6.64 (1H, d, J=7.8Hz), 7.57 (1H, d, J=8.8 Hz), 7.64 (1H, dd, J=8.8, 2.0 Hz), 7.96 (1H, d,J=2.0 Hz) 8.97(1H, br s), 9.27 (1H, s), 11.99 (1H, s). IR (KBr) ν 3410,1626, 1508, 1460, 1330, 1292, 1195, 1125, 1048, 774 cm⁻¹. Mass (FAB);m/z 493 ((M+H)⁺). Elementary Analysis: C₂₇ H₂₈ N₂ O₅ S.CH₃ SO₃ H.0.5H₂O; Calcd.:C, 56.27; H, 5.56; N, 4.69; S, 10.73. Found:C, 56.30; H, 5.74;N, 4.62; S, 10.56.

7 methanesulfonic acid salt (yield 73%)

mp.>:240° C. (decomposed). NMR (400 MHz, DMSO-d6); δ 0.21 (2H, m), 0.41(2H, m), 0.45 (1H, m), 0.50 (1H, m), 0.63 (1H,m), 0.73 (1H, m), 1.02(1H, m), 1.11 (1H, m), 1.83 (1H, m), 2.30 (3H, s), 2.58 (1H, d, J=16.1Hz), 2.60 (1H, m), 2.72 (1H, m), 2.94 (1H, m), 3.00 (1H, d, J=16.1 Hz),3.09-3.18 (3H, m), 3.26 (1H, dd, J=19.6, 6.8 Hz), 3.37 (1H, m), 3.46(1H, d, J=19.6 Hz), 4.08 (1H, br d, J=6.3 Hz), 5.70 (1H, s), 6.38 (1H,br s, OH), 6.60 (1H, d, J=8.1 Hz), 6.64 (1H, d, J=8.1 Hz), 7.37 (1H, d,J=8.8 Hz), 7.67 (1H, dd, J=8.8, 1.5 Hz), 8.00 (1H, br s), 8.34 (1H, t,J=5.6 Hz, NH), 8.95 (1H, m, NH+), 9.25 (1H, br s, OH), 11.59, (1H, s,NH). IR (KBr) ν 3420, 1630, 1620, 1543, 1466, 1328, 1209, 1197, 1116,1048, 870, 818, 785 cm⁻¹. Mass (FAB); m/z 512 ((M+H)⁺). ElementaryAnalysis: C₃₁ H₃₃ N₃ O₄.CH₃ SO₃ H.0.4H₂ O; Calcd.:C, 62.50; H, 6.20; N,6.83; S, 5.21. Found:C, 62.10; H, 6.38; N, 7.00; S, 5.60.

8 methanesulfonic acid salt (yield 40%)

mp.:250° C. (decomposed, methanesulfonic acid salt); NMR (free, 400 MHz,acetone-d6-D₂ O); δ 0.20 (2H, m), 0.54 (2H, m), 0.96 (1H, m), 1.72(1H,m), 2.30 (1H, m), 2.41 (1H, m), 2.48 (1H, d,. J=6.4 Hz), 2.62 (1H, d,J=14.7 Hz) 2.79 (1H, m), 2.86 (1H, m) 2.88 (1H, d, J=15.6 Hz), 3.18 (1H,d, J=18.6 Hz), 3.41 (1H, d, J=6.4 Hz), 5.62 (1H, s), 6.54 (1H, d, J=8.3Hz), 6.60 (1H, d, J=8.3 Hz), 7.39 (1H, dd, J=8.3, 1.5 Hz),7.55 (1H, d,J=7.8 Hz), 7.87 (1H, d, J=1.0 Hz) IR (KBr) ν 3370, 2220, 1622, 1462,1325, 1116, 870 cm⁻¹. Mass (EI); m/z 439 (M⁺). Elementary Analysis: C₂₇H₂₅ N₃ O₃.1.1CH₃ SO₃ H.0.5H₂ O; Calcd.:C, 60.90; H, 5.53; N, 7.58; S,6.36 Found:C, 60.72; H, 5.82; N, 7.62; S, 6.31

9 dimethanesulfonic acid salt (yield 35%)

mp.>210° C. (decomposed). NMR (500 MHz, DMSO-d6); δ 0.44 (1H, m), 0.50(1H, m), 0.63 (1H, m), 0.72 (1H, m), 1.11 (1H, m), 1.83 (1H, m), 2.32(6H, s), 2.52 (1H, m), 2.60 (1H, m), 2.71 (1H, m), 2.80 (6H, s),2.90-3.01 (4H, m), 3.12 (1H, m), 3.18-3.50 (5H, m), 4.06 (1H, m), 5.68(1H, s), 6.33 (1H, br s, OH), 6.58 (1H, d, J=7.9 Hz), 6.62 (1H, d, J=7.9Hz), 7.03 (1H, br d, J=8.5 Hz), 7.25 (1H, s), 7.33 (1H, d, J=8.5 Hz),8.92 (1H, m, NH⁺), 9.20 (1H, br s, OH), 9.31 (1H, m, NH⁺), 11.30 (1H, s,NH). IR (KBr) ν 3410, 1649, 1638, 1626, 1460, 1330, 1197, 1052, 783cm⁻¹. Mass (FAB); m/z 486 ((M+H)⁺). Elementary Analysis: C₃₀ H₃₅ N₃O₃.2CH₃ SO₃ H.1.1H₂ O; Calcd.:C, 55.09; H, 6.53; N, 6.02; S, 9.19.Found:C, 55.09; H, 6.91; N, 5.83; S, 9.18.

10 methanesulfonic acid salt (yield 55%)

mp.>180° C. (decomposed). NMR (400 MHz, DMSO-d6); δ 0.44 (1H, m), 0.51(1H, m), 0.63 (1H, m), 0.73 (1H, m), 1.11 (1H,m), 1.84 (1H, m), 2.30(6H, s), 2.48-2.78 (3H, m), 2.67 (3H, s), 2.69 (3H, s), 2.89-2.98 (2H,m), 3.14 (1H, m), 3.27 (1H, dd, J=20.0, 6.3 Hz), 3.39 (1H, m), 3.46 (1H,d, J=20.0 Hz), 4.07 (1H, m), 4.26-4.34 (2H, m), 5.70 (1H, s), 6.35 (1H,s, OH), 6.59 (1H, d, J=8.1 Hz), 6.63 (1H, d, J=8.1 Hz), 7.23 (1H, br d,J=8.3 Hz), 7.45 (1H, d, J=8.3 Hz), 7.46 (1H, s), 8.92 (1H, m, NH+), 9.23(1H, s, OH), 9.39 (1H, m, NH⁺), 11.59 (1H, s, NH). IR (KBr) ν 3380,1638, 1626, 1466, 1330, 1197, 1116, 1060, 936, 785 cm⁻¹. Mass (FAB); m/z472 ((M+H)⁺). Elementary Analysis: C₂₉ H₃₃ N₃ O₃.2CH₃ SO₃ H.0.7H₂ O;Calcd.:C, 55.05; H, 6.32; N, 6.21; S, 9.48. Found:C, 54.90; H, 6.55; N,6.17; S, 9.43.

Example 2

17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan40 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan41 ##STR15##

A reaction was carried out in the similar manner as in Example 1 using1.64 g of naltrexone hydrochloric acid salt, 1.19 g of3-(2-hydroxyethyl)phenylhydrazine, 0.59 ml of methanesulfonic acid and33 ml of ethanol. The reaction product was purified by columnchromatography silica gel; chloroform:methanol:28% aqueous ammoniasolution (90:10:0.1)! to obtain 503 mg (yield 27%) and 1200 mg (yield60%) of the captioned compounds, respectively.

40 methanesulfonic acid salt

mp.>228° C. (decomposed); NMR (400 MHz, DMSO-d6); δ 0.40-0.78 (4H, m),1.07-1.18 (1H, m), 1.85 (1H, br d J=21.0 Hz), 2.30 (3H, s), 2.53-2.78(2H, m), 2.74 (1H, d, J=15.6 Hz), 2.89-2.98 (1H, m), 2.98 (2H, t, J=7.5Hz), 3.11 (1H, br d, J=11.2 Hz), 3.19 (1H, d, J=16.1 Hz), 3.20-3.68 (5H,m), 4.05 (1H, br d, J=5.9 Hz), 4.55 (1H, br s), 5.66 (1H, s), 6.37 (1H,s), 6.60 (1H, d, J=8.3 Hz), 6.63 (1H, d, J=8.3 Hz), 6.73 (1H, d,J=7.3Hz), 6.98 (1H, t, J=7.3 Hz), 7.18 (1H, t, J=7.3 Hz), 8.91 (1H, br s),9.21 (1H, br s), 11.31 (1H, s). IR(KBr) ν 3400, 1620, 1508, 1462, 1332,1195, 1116, 1050, 785cm⁻¹. Mass (FAB); m/z 459 ((M+H)⁺). ElementaryAnalysis: C₂₈ H₃₀ N₂ O₄.CH₃ SO₃ H.0.4H₂ O; Calcd.:C, 61.99; H, 6.24; N,4.99; S, 5.71. Found:C, 61.96; H, 6.29; N, 5.13; S, 5.67.

41 methanesulfonic acid salt

mp.>204° C. (decomposed); NMR (400 MHz, DMSO-d6); δ 0.38-0.55 (2H, m),0.57-0.78 (2H, m), 1.04-1.15 (1H, m), 1.81 (1H, br d, J=11.2 Hz), 2.32(3H, s), 2.48-2.80 (3H, m), 2.78 (2H, t, J=7.1 Hz), 2.92 (1H, d, J=16.1Hz), 2.87-2.98 (1H, m), 3.11 (1H, br d, J=11.7 Hz), 3.25 (1H, dd,J=19.5, 6.8 Hz), 3.30-3.50 (3H, m), 3.57 (2H, t, J=7.1 Hz), 4.07 (1H, d,J=6.4 Hz), 5.66 (1H, s), 6.31 (1H, br s), 6.58 (1H, d, J=8.3 Hz), 6.62(1H, d, J=8.3 Hz), 6.83 (1H, dd, J=7.8, 1.2 Hz), 7.18 (1H, br s), 7.23(1H, d, J=7.8 Hz), 8.91 (1H, br s), 9.18 (1H, br s), 11.16 (1H, s).IR(KBr) ν 3420, 1620, 1510, 1462, 1330, 1199, 1116, 1048, 785 cm⁻¹. Mass(FAB); m/z 459 ((M+H)⁺). Elementary Analysis: C₂₈ H₃₀ N₂ O₄.CH₃ SO₃H.0.6H₂ O; Calcd.:C, 61.60; H, 6.27; N, 4.95; S. 5.67. Found:C, 61.62;H, 6.32; N, 4.93; S, 5.76.

By using 3-methylthiophenylhydrazine in place of3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan42 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43 are obtained. By using3-(N-cyclopropylmethylsulfamoyl)phenylhydrazine in place of3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan44 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan45 are obtained. By using3-(N-cyclopropylmethylcarbamoyl)phenylhydrazine in place of3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan46 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan47 are obtained. By using 3-ethoxycarbonylmethylphenylhydrazine in placeof 3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan48 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan49 are obtained. By using 3-(N,N-dimethylsulfamoyl)phenylhydrazine inplace of 3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan50 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan51 are obtained. By using 3-cyanophenylhydrazine in place of3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5.alpha.-epoxy-3,14β-dihydroxy-4'-cyano-6,7-2',3'-indolomorphinan52 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-cyano-6,7-2',3'-indolomorphinan53 are obtained. By using 3-trifluoromethylphenylhydrazine in place of3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-trifluoromethyl-6,7-2',3'-indolomorphinan54 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-trifluoromethyl-6,7-2',3'-indolomorphinan55 are obtained. By using 3-phenylphenylhydrazine in place of3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-phenyl-6,7-2',3'-indolomorphinan56 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-phenyl-6,7-2',3'-indolomorphinan57 are obtained. By using 3-trifluoromethoxyphenylhydrazine in place of3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-trifluoromethoxy-6,7-2',3'-indolomorphinan58 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-trifluoromethoxy-6,7-2',3'-indolomorphinan59 are obtained. By using 3-sulfamoylphenylhydrazine in place of3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-sulfamoyl-6,7-2',3'-indolomorphinan60 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-sulfamoyl-6,7-2',3'-indolomorphinan61 are obtained. By using 3-iodophenylhydrazine in place of3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-iodo-6,7-2',3'-indolomorphinan62 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-iodo-6,7-2',3'-indolomorphinan63 are obtained. By using 3- 2-(N,N-dimethylamino)ethyl)!phenylhydrazinein place of 3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 64 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 65 are obtained.By using 3-(N,N-dimethylamino)methylphenylhydrazine in place of3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan66 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan67 are obtained. By using 1-methyl-1-(3-methylthiophenyl)hydrazine inplace of 3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-methylthio-6,7-2',3'-indolomorphinan68 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-methylthio-6,7-2',3'-indolomorphinan69 are obtained. By using 1-methyl-1-(3-phenylphenyl)hydrazine in placeof 3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-phenyl-6,7-2',3'-indolomorphinan 70 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-phenyl-6,7-2',3'-indolomorphinan71 are obtained. By using 1-methyl-1- 3-2-(N,N-dimethylamino)ethyl)!phenyl!hydrazine in place of3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 72 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 73 are obtained.By using 1-methyl- 3-(N,N-dimethylamino)methylphenyl!hydrazine in placeof 3-(2-hydroxyethyl)phenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan74 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan75 are obtained.

By using 3-methoxycarbonylphenylhydrazine in place of3-(2-hydroxyethyl)phenylhydrazine and by using methanol in place ofethanol,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan76 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan77 are obtained.

By using 3-nitrophenylhydrazine in place of3-(2-hydroxyethyl)phenylhydrazine and by using acetic acid-12Nhydrochloric acid (4:1) in place of ethanolmethanesulfonic acid,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan78 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-nitro-6,7-2',3'-indolomorphinan79 are obtained.

By using naloxone hydrochloric acid salt in place of naltrexonehydrochloric acid salt and by using 3-(2-hydroxyethyl)phenylhydrazine,3-methylthiophenylhydrazine,3-(N-cyclopropylmethylsulfamoyl)phenylhydrazine,3-(N-cyclopropylmethylcarbamoyl)phenylhydrazine,3-ethoxycarbonylmethylphenylhydrazine,3-(N,N-dimethylsulfamoyl)phenylhydrazine, 3-cyanophenylhydrazine,3-trifluoromethylphenylhydrazine, 3-phenylphenylhydrazine,3-trifluromethoxyphenylhydrazine, 3-sulfamoylphenylhydrazine,3-iodophenylhydrazine, 3- 2-(N,N-dimethylamino)ethyl)!phenylhydrazine,3-(N,N-dimethylamino)methylphenylhydrazine,1-methyl-1-(3-methylthiophenyl)hydrazine,1-methyl-1-(3-phenylphenyl)hydrazine, 1-methyl-1- 3-2-(N,N-dimethylamino)ethyl)!phenyl!hydrazine or 1-methyl-3-(N,N-dimethylamino)methylphenyl!hydrazine as the phenylhydrazinederivative,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan80,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan81,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan82,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan83,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan84,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan85,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan86,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan87,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan88,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan89,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-cyano-6,7-2',3'-indolomorphinan90,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-cyano-6,7-2',3'-indolomorphinan91,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-trifluoromethyl-6,7-2',3'-indolomorphinan92,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-trifluoromethyl-6,7-2',3'-indolomorphinan93,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-phenyl-6,7-2',3'-indolomorphinan94,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-phenyl-6,7-2',3'-indolomorphinan95,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-trifluoromethoxy-6,7-2',3'-indolomorphinan96,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-trifluoromethoxy-6,7-2',3'-indolomorphinan97,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-sulfamoyl-6,7-2',3'-indolomorphinan98,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-sulfamoyl-6,7-2',3'-indolomorphinan99,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-iodo-6,7-2',3'-indolomorphinan100,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-iodo-6,7-2',3'-indolomorphinan101, 17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 102,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 103,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan104,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan105,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-methylthio-6,7-2',3'-indolomorphinan106,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-methylthio-6,7-2',3'indolomorphinan107,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-phenyl-6,7-2',3'-indolomorphinan108,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-phenyl-6,7-2',3'-indolomorphinan109, 17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 110,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 111,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan112 and17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan113 are obtained, respectively.

By using naloxone hydrochloric acid salt and3-methoxycarbonylphenylhydrazine in place of naltrexone hydrochloricacid salt and 3-(2-hydroxyethyl)phenylhydrazine, and by using methanolin place of ethanol,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan114 and17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan115 are obtained.

By using naloxone hydrochloric acid salt and 3-nitrophenylhydrazine inplace of naltrexone hydrochloric acid and3-(2-hydroxyethyl)phenylhydrazine, and by using acetic acid--12Nhydrochloric acid (4:1) in place of ethanol-methanesulfonic acid,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan116 and17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-nitro-6,7-2',3'-indolomorphinan117 are obtained.

43 methanesulfonic acid salt (yield 57%)

mp.>225° C. (decomposed); NMR (400 MHz, CDCl3, data for free base); δ0.11-0.21 (2H, m), 0.51-0.62 (2H, m), 0.83-0.93 (1H, m), 1.71 (1H, br d,J=11.2 Hz), 2.19-2.47 (4H, m), 2.47 (1H, br s), 2.47 (3H, s), 2.60 (1H,d, J=15.6 Hz), 2.63-2.71 (1H, m), 2.78 (1H, dd, J=6.4, 18.6 Hz),2.85(1H, d, J=15.6 Hz), 3.09 (1H, d, J=18.6 Hz), 3.36 (1H, d, J=6.4 Hz),5.48 (1H, br s), 5.68 (1H, s), 6.42 (1H, d, J=8.1 Hz), 6.51 (1H, d,J=8.1 Hz), 6.97 (1H, dd, J=1.5, 8.1 Hz), 7.10 (1H, br s), 7.26 (1H, d,J=8.3 Hz), 8.18 (1H, s). IR (KBr) ν 3400 ,1620, 1510, 1460, 1328, 1209,1048 cm⁻¹ Mass (EI); m/z 460 (M⁺). Elementary Analysis: C₂₇ H₂₈ N₂ O₃S.CH₃ SO₃ H.0.6H₂ O; Calcd.: C., 59.26; H, 5.90; N, 4.94; S, 11.30.Found: C., 59.21; H, 5.86; N, 4.90; S, 11.38.

45 methanesulfonic acid salt (yield 45%)

mp.>300° C. (decomposed, ether); NMR (400MHz, DMSO-d6); δ 0.03 (2H, m),0.3 (2H, m), 0.44 (1H, m), 0.50 (1H, m), 0.63 (1H, m), 0.74 (2H, m),1.09 (1H, m), 1.84 (1H, br d, J=12.7 Hz), 2.30 (3H, s), 2.50 (2H, m),2.54˜2.58 (2H, m), 2.63 (1H, m), 2.72 (1H, m), 2.95 (1H, m), 2.99 (1H,d, J=16.1 Hz), 3.12 (1H, br d, J=8.8 Hz), 3.26 (1H, dd, J=20.0, 7.3 Hz),3.45 (1H, d, J=20.0 Hz), 4.09 (1H, d, J=9.4 Hz), 5.75 (1H, s), 6.37 (1H,s), 6.61 (1H, d, J=8.3 Hz), 6.64 (1H, d, J=8.3 Hz), 7.40 (1H, dd, J=8.3,1.2 Hz), 7.52 (1H, d, J=8.3 Hz), 7.55 (1H, t, J=5.9 Hz ), 7.82 (1H, d,J=1.2 Hz), 8.95 (1H, br s), 9.26 (1H, s), 11.87 (1H, s). IR (KBr) ν3400, 1635, 1626, 1506, 1480, 1311, 1210, 1190, 1149, 1050, 872, 785cm⁻¹. Mass (FAB); m/z 548 ((M+H)⁺). Elementary Analysis: C₃₁ H₃₇ N₃ O₈S₂.0.3H₂ O; Calcd.: C., 57,35; H, 5.84; N, 6.47; S, 9.89. Found: C.,57,17; H, 5.99; N, 6.38; S, 9.79.

46 methanesulfonic acid salt (yield 18%)

mp.>235° C. (decomposed). NMR (500 MHz, DMSO-d6); δ 0.23 (2H, m),0.39-0.47 (3H, m), 0.49 (1H, m), 0.63 (1H, m), 0.72 (1H, m), 1.02 (1H,m), 1.13 (1H, m), 1.81 (1H, m), 2.30 (3H, s), 2.58 (1H, d, J=16.5 Hz),2.61 (1H, m), 2.72 (1H, m), 2.92 (1H, m), 2.97 (1H, m), 3.02 (1H, d,J=16.5 Hz), 3.08-3.16 (2H, m), 3.23 (1H, m), 3.39 (1H, m), 3.46 (1H, d,J=20.1 Hz), 3.98 (1H, br d, J=6.1 Hz), 5.69 (1H, s), 6.25 (1H, br s,OH), 6.61 (1H, d, J=8.3 Hz), 6.64 (1H, d, J=8.3 Hz), 7.04 (1H, dd,J=7.3, 1.2 Hz), 7.12 (1H, dd, J=7.9, 7.3 Hz), 7.44 (1H, dd, J=7.9, 1.2Hz), 8.31 (1H, t, J=5.5 Hz, NH), 8.87 (1H, m, NH⁺), 9.21 (1H, br s, OH),11.55 (1H, s, NH). IR (KBr) ν 3332, 1638, 1620, 1535, 1460, 1328, 1197,1164, 1116, 1050, 803, 779 cm⁻¹. Mass (FAB); m/z 512 ((M+H)⁺).Elementary Analysis: C₃₁ H₃₃ N₃ O₄.CH₃ SO₃ H.0.3H₂ O; Calcd.: C., 62.69;H, 6.18; N, 6.85; S, 5.23. Found: C., 62.60; H, 6.10; N, 7.01; S, 5.55.

47 methanesulfonic acid salt (yield 25%)

mp.>220° C. (decomposed). NMR (500 MHz, DMSO-d6); δ 0.23 (2H, m),0.40-0.47 (3H, m), 0.50 (1H, m), 0.63 (1H, m), 0.73 (1H, m), 1.05 (1H,m), 1.10 (1H, m), 1.83 (1H, m), 2.30 (3H, s), 2.56 (1H, d, J=15.9 Hz),2.61 (1H, m), 2.72 (1H, m), 2.94 (1H, m), 2.98 (1H, d, J=15.9 Hz),3.09-3.18 (3H, m), 3.26 (1H, dd, J=19.5, 6.7 Hz), 3.39 (1H, m), 3.44(1H, d, J=19.5 Hz), 4.08 (1H, br d, J=6.7 Hz), 5.72 (1H, s), 6.37 (1H,br s, OH), 6.60 (1H, d, J=7.9 Hz), 6.64 (1H, d, J=7.9 Hz), 7.39 (1H, d,J=8.5 Hz), 7.53 (1H, dd, J=8.5, 1.2 Hz), 7.93 (1H, br s), 8.45 (1H, t,J=5.8 Hz, NH), 8.93 (1H, m, NH⁺), 9.23 (1H, s, OH), 11.63, (1H, s, NH).IR (KBr) ν 3400, 1620, 1545, 1462, 1330, 1195, 1116, 1048, 820, 772cm⁻¹. Mass (FAB); m/z 512 ((M+H)⁺). Elementary Analysis: C₃₁ H₃₃ N₃O₄.CH₃ SO₃ H.0.4H₂ O; Calcd.: C., 62.50; H, 6.20; N, 6.83; S, 5.21.Found: C., 62.29; H, 6.41; N, 7.04; S, 5.18.

48 methanesulfonic acid salt (yield 14%)

mp.>180° C. (decomposed); NMR (400 MHz, DMSO-d6); δ 0.38-0.77 (4H, m),1.10 (3H, t, J=6.6 Hz), 1.08-1.18 (1H, m), 1.81 (1H, br d, J=11.7 Hz),2.32 (3H, s), 2.53-2.79 (2H, m), 2.70 (1H, d, J=15.6 Hz), 2.87-2.97 (1H,m), 3.08-3.23 (2H, m), 3.15 (1H, d, J=15.6 Hz), 3.27-3.50 (2H, m), 3.82(1H, d, J=15.6 Hz), 3.96 (1H, d, J=15.6 Hz), 3.95-4.07 (3H, m), 5.67(1H, s), 6.38 (1H, br s), 6.59 (1H, d, J=8.1 Hz), 6.64 (1H, d, J=8.1Hz), 6.76 (1H, d, J=7.3 Hz), 7.02 (1H, t, br s), 7.26 (1H, d, J=7.3 Hz),8.93 (1H, br s), 9.21(1H, br s), 11.41 (1H, s). IR (KBr) ν 3420, 1719,1620, 1508, 1466, 1330, 1183, 1116, 1048 cm⁻¹ Mass (FAB); m/z 501(M+H).⁺ Elementary Analysis: C₃₀ H₃₂ N₂ O₅.CH₃ SO₃ H.0.5H₂ O; Calcd.:C., 61.11; H, 6.19; N, 4.60; S, 5.26. Found: C., 60.87; H, 6.40; N,4.60; S, 5.61.

49 methanesulfonic acid salt (yield 43%)

mp.>160° C. (decomposed); NMR (free, 400 MHz, CDCl3); δ 0.11-0.22 (2H,m), 0.51-0.62 (2H, m), 0.83-0.93 (1H, m), 1.20 (3H, t, J=7.1 Hz), 1.73(1H, br d, J=11.5 Hz), 2.27 (1H, dt, J=2.9, 11.5 Hz), 2.33-2.44 (2H, m),2.44 (1H, dd, J=6.6, 12.5 Hz), 2.60 (1H, d, J=15.6 Hz), 2.70 (1H, dd,J=4.1, 11.5 Hz), 2.77 (1H, dd, J=6.4, 18.6 Hz), 2.86 (1H, d, J=16.1 Hz),3.09 (1H,d, J=18.6 Hz), 3.35 (1H, d, J=6.4 Hz), 3.63 (2H, s), 4.10 (2H,q, J=7.1 Hz), 5.00 (2H, br s), 5.67 (1H, s), 6.44 (1H, d, J=8.3 Hz),6.52 (1H, d, J=8.3 Hz), 6.91 (1H, dd, J=1.0, 8.3 Hz), 7.12 (1H, br s),7.32 (1H, d, J=8.3 Hz), 8.33 (1H, s). IR (KBr) ν 3420, 1720, 1630, 1510,1460, 1330, 1116, 1048 cm⁻¹. Mass (FAB); m/z 501 ((M+H)⁺). ElementaryAnalysis: C₃₀ H₃₂ N₂ O₅.CH₃ SO₃ H.0.5H₂ O; Calcd.: C., 61.47; H, 6.16;N, 4.62; S, 5.29. Found: C., 61.45; H, 6.13; N, 4.74; S, 5.48.

51 methanesulfonic acid salt (yield 24%)

mp.: 270.0°, ˜272.0° C. (decomposed, ether); NMR (400 MHz,DMSO d6); δ0.44 (1H, m), 0.50 (1H, m), 0.64 (1H, m), 0.74 (1H, m), 1.10 (1H,m),1.85 (1H, d, J=11.0 Hz), 2.30 (3H, s), 2.56 (6H, s), 2.57-2.65 (2H, m),2.72 (1H, m), 2.96 (1H, m), 3.01 (1H, d, J=16.9 Hz), 3.13 (1H, br d,J=11.6 Hz), 3.26 (1H, dd, J=19.8, 7.3 Hz), 3.35-3.49 (2H, m), 4.10 (1H,d, J=7.3 Hz), 5.75 (1H, s), 6.38 (1H, s), 6.61 (1H, d, J=7.9 Hz), 6.64(1H, d, J=7.9 Hz), 7.33 (1H, dd, J=8.2, 1.5 Hz), 7.59 (1H, d, J=8.2 Hz),7.76 (1H, d, J=1.5 Hz), 9.00 (1H, br s), 9.26 (1H, s), 11.92 (1H, s). IR(KBr) ν 3400, 1626, 1508, 1325, 1152, 951, 770, 721 cm⁻¹. Mass (FAB);m/z 522 ((M+H)⁺). Elementary Analysis: C₂₉ H₃₅ N₃ O₈ S₂.1.0H₂ O;Calcd.:C, 54.79; H, 5.55; N, 6.61; S, 10.09. Found:C, 54.67; H, 5.79; N,6.66; S, 9.87.

53 methanesulfonic acid salt (yield 18%)

mp.: 250° C. (decomposed); NMR (free, 400 MHz, acetone-d6-D20); δ 0.23(2H, m), 0.59 (2H, m), 0.98 (1H, m), 1.76(1H, m), 2.34 (1H, m), 2.46(1H, m), 2.51 (1H, d,. J=6.3 Hz), 2.65 (1H, d, J=15.6 Hz) 2.82 (1H, m),2.90 (1H, m) 2.89 (1H, d, J=15.6 Hz), 3.23 (1H, d, J=18.6 Hz), 3.43 (1H,d, J=6.3 Hz), 5.66 (1H, s), 6.59 (1H, d, J=8.3 Hz), 6.65 (1H, d, J=8.3Hz), 7.28 (1H, dd, J=8.3, 1.5 Hz), 7.55 (1H, d, J=8.3 Hz), 7.76 (1H, s)IR (KBr) ν 3320, 2220, 1620, 1502, 1332, 1116, 820 cm⁻¹. Mass (EI); m/z439 (M⁺). Elementary Analysis: C₂₇ H₂₅ N₃ O₃.1.2CH₃ SO₃ H.0.7H₂ O;Calcd.: C., 59.69; H, 5.54; N, 7.40; S, 6.78. Found: C., 59.79; H, 5.67;N, 7.45; S, 6.57.

76 methanesulfonic acid salt (yield 32%)

mp.>230° C. (decomposed). NMR (400 MHz, DMSO-d6); δ 0.44 (1H, m), 0.52(1H, m), 0.63 (1H, m), 0.73 (1H, m), 1.12 (1H, m), 1.83 (1H, m), 2.30(3H, s), 2.57 (1H, m), 2.64 (1H, d, J=16.6 Hz), 2.73 (1H, m), 2.86 (1H,m), 3.10 (1H, m), 3.17 (1H, d, J=16.6 Hz), 3.24 (1H, dd, J=20.0, 7.3Hz), 3.37-3.48 (2H, m), 3.83 (3H, s), 4.03 (1H, br d, J=7.8 Hz), 5.70(1H, s), 6.20 (1H, br s, OH), 6.62 (1H, d, J=8.3 Hz), 6.65 (1H, d, J=8.3Hz), 7.19 (1H, dd, J=7.8, 7.8 Hz), 7.52 (1H, d, J=7.8 Hz), 7.63 (1H, d,J=7.8 Hz), 8.89 (1H, br s, NH⁺), 9.26 (1H, br s ,OH), 11.82 (1H, s, NH).IR (KBr) ν 3400, 1709, 1638, 1620, 1508, 1462, 1437, 1330, 1303, 1270,1205, 1118, 1046, 926, 870, 814, 770, 756 cm⁻¹. Mass (FAB); m/z 473((M+H)⁺). Elementary Analysis: C₂₈ H₂₈ N₂ O₅.CH₃ SO₃ H.0.6H₂ O; Calcd.:C., 60.11; H, 5.77; N, 4.83; S, 5.53. Found: C., 60.04; H, 5.80; N,4.88; S, 5.63.

77 methanesulfonic acid salt (yield 47%)

mp.>240° C. (decomposed). NMR (400 MHz, DMSO-d6); δ 0.44 (1H, m), 0.50(1H, m), 0.63 (1H, m), 0.74 (1H, m), 1.10 (1H, m), 1.84 (1H, m), 2.31(3H, s), 2.56 (1H, d, J=16.1 Hz), 2.61 (1H, m), 2.72 (1H, m), 2.94 (1H,m), 2.99 (1H, d, J=16.1 Hz), 3.12 (1H, m), 3.26 (1H, dd, J=19.8, 6.5Hz), 3.39 (1H, m), 3.45 (1H, d, J=19.8 Hz), 3.85 (3H, s), 4.08 (1H, brd, J=7.8 Hz),5.75 (1H, s), 6.39 (1H, br s, OH), 6.61 (1H, d, J=8.1 Hz),6.64 (1H, d, J=8.1 Hz), 7.46 (1H, d, J=8.3 Hz), 7.61 (1H, dd, J=8.3, 1.5Hz), 8.02 (1H, br s), 8.95 (1H, m, NH⁺), 9.28 (1H, br s, OH), 11.81 (1H,s, NH). IR (KBr) ν 3382, 1698, 1626, 1508, 1460, 1437, 1330, 1212, 1116,1044, 872, 774 cm⁻¹. Mass (FAB); m/z 473 ((M+H)⁺). Elementary Analysis:C₂₈ H₂₈ N₂ O₅.CH₃ SO₃ H; Calcd.: C., 61.25; H, 5.67; N, 4.93; S, 5.64.Found: C., 61.04; H, 5.93; N, 4.93; S, 5.58.

78 methanesulfonic acid salt (yield 10%)

mp.: 220° C. (decomposed); NMR (400 MHz, DMSO-d6); δ 0.44 (1H, m), 0.50(1H, m), 0.63 (1H, m), 0.74(1H, m), 1.12 (1H,m), 1.85 (1H, br d , J=10.7Hz), 2.30 (3H, s), 2.59 (1H, m), 2.67 (1H, d,. J=16.6 Hz), 2.74 (1H, m),2.89 (1H, m), 3.06 (1H, d, J=16.6 Hz), 3.11 (1H, m), 3.25 (1H, dd,J=19.5, 6.8 Hz), 3.40-3.48 (2H,m), 4.07 (1H, d, J=6.8 Hz), 5.75 (1H, s),6.23 (1H, s), 6.64 (1H, d, J=8.3 Hz), 6.67 (1H, d, J=8.3 Hz), 7.29(1H,dd, J=8.3, 7.8 Hz), 7.77 (1H, dd, J=8.3, 1.0 Hz), 7.81 (1H, dd, J=7.8,1.0 Hz), 8.90 (1H, br s), 9.29 (1H, br s), 12.31 (1H, s). IR (KBr) ν3420, 1510, 1350, 1328, 1197, 1040, 557 cm⁻¹. Mass (FAB); m/z 458((M-H)⁻). Elementary Analysis: C₂₆ H₂₅ N₃ O₅.CH₃ SO₃ H.0.5H₂ O; Calcd.:C., 57.44; H, 5.36; N, 7.44; S, 5.68. Found: C., 57.51; H, 5.25; N,7.24; S, 5.65.

79 methanesulfonic acid salt (yield 38%)

mp.: 250° C. (decomposed); NMR (400 MHz, DMSO-d6); δ 0.44 (1H, m), 0.50(1H, m), 0.63 (1H, m), 0.73(1H, m), 1.10 (1H, m), 1.85 (1H, br d, J=11.7Hz), 2.29 (3H, s) 2.58 (1H, d,. J=16.1 Hz), 2.60 (1H, m), 2.73 (1H, m),2.94 (1H, m) 3.02 (1H, d, J=16.1 Hz), 3.12 (1H, m), 3.26 (1H, dd,J=20.0, 6.8 Hz), 3.40 (1H,m), 3.46 (1H, d, J=20.0 Hz), 4.09 (1H, d,J=6.8 Hz), 5.78 (1H, s), 6.42 (1H, s), 6.62 (1H, d, J=8.3 Hz), 6.65 (1H,d, J=8.3 Hz), 7.57 (1H, d, J=8.8 Hz), 7.88 (1H, dd, J=8.8, 2.0 Hz), 8.30(1H, d, J=2.0 Hz), 8.97(1H, br s), 9.29 (1H, s), 12.21 (1H, s). IR (KBr)ν 3390, 1510, 1466, 1328, 1197, 1116, 1060, 820, 785 cm⁻¹. Mass (FAB);m/z 458 ((M-H)⁻). Elementary Analysis: C₂₆ H₂₅ N₃ O₅.CH₃ SO₃ H.0.7H₂ O;Calcd.: C., 57.07; H, 5.39; N, 7.39; S, 5.64. Found: C., 57.20; H, 5.69;N, 7.24; S, 5.67.

114 methanesulfonic acid salt (yield 28%)

mp.: 220° C. (decomposed); NMR (free, 500 MHz, CDCl₃ -D₂ O); δ 1.64 (1H,d, J=11.6 Hz), 2.23 (2H, m), 2.51 (1H, m), 2.73 (1H, d, J=15.9 Hz), 2.75(1H, m), 3.03 (1H, d, J=18.3 Hz), 3.09 (3H, m), 3.15 (1H, d, J=17.1 Hz),3.79 (3H, s), 5.12 (2H, m), 5.53 (1H, s), 5.75 (1H, m), 6.36 (1H, d,J=7.9 hz), 6.43 (1H, d, J=7.9 Hz), 6.98 (1H, t, J=7.9 Hz), 7.24 (1H, d,J=9.2), 7.49 (1H, dd, J=7.3, 1.2 Hz) IR (KBr) ν 3320, 1702, 1502, 1294,1137, 752 cm⁻¹. Mass (FAB); m/z 459 ((M+H)⁺). Elementary Analysis: C₂₇H₂₆ N₂ O₅.CH₃ SO₃ H.0.5H₂ O; Calcd.: C., 59.67; H, 5.54; N, 4.97; S,5.69. Found: C., 59.62; H, 5.68; N, 4.87; S, 5.83.

115 methanesulfonic acid salt (yield 42%)

mp.: 200° C. (decomposed); NMR (free, 500 MHz, CDCl₃ -D₂ O); δ 2.28 (2H,m), 2.51 (1H, d, J=15.8 Hz), 2.55 (1H, m), 2.78 (1H, d, J=15.8 Hz), 2.80(1H, m), 3.15 (4H, m), 3.89 (3H, s), 5.21 (2H, m), 5.64 (1H, s), 5.82(1H, m), 6.50 (1H, d, J=8.4 Hz), 6.56 (1H, d, J=8.1 Hz), 7.52 (1H, d,J=8.4 Hz), 7.53 (1H, dd, J=8.4, 1.5 Hz), 7.56 (1H, s) IR (KBr) ν 3320,1698, 1626, 1504, 1212, 1096, 768 cm⁻¹. Mass (FAB); m/z 458 ((M+H)⁺);Elementary Analysis: C₂₇ H₂₆ N₂ O₅.CH₃ SO₃ H.0.5H₂ O; Calcd.: C., 59.67;H, 5.54; N, 4.97; S, 5.69. Found: C., 59.65; H, 5.81; N, 4.77; S, 5.69.

Example 3

17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-trifluoromethyl-6,7-2',3'-indolomorphinan118 ##STR16##

Using 2.00 g of naltrexone hydrochloric acid salt, 1.02 g of2-trifluoromethylphenylhydrazine, 3.44 ml of methanesulfonic acid and 40ml of ethanol, the reaction and purification as in Example 1 werecarried out to obtain 1.07 g of methanesulfonic acid salt of thecaptioned compound (yield 35%).

118 methanesulfonic acid salt

mp.: 256.0°˜261° C. (decomposed, ether); NMR (400 Hz, DMSO-d6); δ 0.45(1H, m), 0.50 (1H, m), 0.64 (1H, m), 0.73 (1H, m), 1.10 (1H, m), 1.86(1H, br d , J=11.2 Hz), 2.30 (3H, s), 2.50 (1H, m), 2.56 (1H, d, J=16.1Hz), 2.61 (1H, m), 2.74 (1H, m), 2.94 (1H, m), 2.99 (1H, d, J=16.1 Hz),3.12 (1H, m), 3.26 (1H, dd, J=19.7, 6.6 Hz), 3.40 (1H, m), 3.46 (1H, d,J=19.7 Hz), 4.10 (1H, br d, J=6.4 Hz), 5.70 (1H, s), 6.40 (1H, s), 6.61(1H, d, J=8.3 Hz), 6.66 (1H, d, J=8.3 Hz), 7.16 (1H, dd, J=7.8, 7.3 Hz),7.48 (1H, d, J=7.3 Hz), 7.68 (1H, d, J=7.8 Hz), 8.95 (1H, br s), 9.27(1H, s), 11.76 (1H, s). IR (KBr) ν 3400, 1638, 1628, 1508, 1466, 1317,1200, 1120, 1048, 872, 781, 748 cm⁻¹. Mass (FAB); m/z 483 ((M+H)⁺).Elementary Analysis: C₂₈ H₂₉ F₃ N₂ O₆ S₁.0.3H₂ O; Calcd.:C, 57.59; H,5.11; N, 4.80; F, 9.76; S, 5.49. Found:C, 57.59; H, 5.24; N, 4.80; F,9.80; S, 5.42.

By using 2-ethoxycarbonylphenylhydrazine, 2-phenylphenylhydrazine,2-methylthiophenylhydrazine, 2-(2-hydroxyethyl)phenylhydrazine,2-(N-cyclopropylmethylsulfamoyl)phenylhydrazine,2-(N,N-dimethylsulfamoyl)phenylhydrazine, 2-sulfamoylphenylhydrazine,2-ethoxycarbonylmethylphenylhydrazine,2-(N-cyclopropylmethylcarbamoyl)phenylhydrazine,2-trifluoromethoxyphenylhydrazine, 2-iodophenylhydrazine,2-(N,N-dimethylamino)methylphenylhydrazine, 2-2-(N,N-dimethylamino)ethyl!phenylhydrazine,1-methyl-1-(2-methylthiophenyl)hydrazine,1-methyl-1-(2-phenylphenyl)hydrazine, 1-methyl-1- 2-2-(N,N-dimethylamino)ethyl)!phenyl!hydrazine or 1-methyl-2-(N,N-dimethylamino)methylphenyl!hydrazine in place of2-trifluoromethylphenylhydrazine,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan119,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-phenyl-6,7-2',3'-indolomorphinan120,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan121,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan122,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan123,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan124,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-sulfamoyl-6,7-2',3'-indolomorphinan125,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan126,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan127,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-trifluoromethoxy-6,7-2',3'-indolomorphinan128,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-iodo-6,7-2',3'-indolomorphinan129,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan130, 17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-2-(N,N-dimethylamino)ethyl!-6,7-2',3'-indolomorphinan 131,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-methylthio-6,7-2',3'-indolomorphinan132,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-phenyl-6,7-2',3'-indolomorphinan133,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-2-(N,N-dimethylamino)ethyl!-6,7-2',3'-indolomorphinan 134 and17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan135 are obtained, respectively.

By using 2-nitrophenyl:hydrazine in place of2-trifluoromethylphenylhydrazine and by using acetic acid--12Nhydrochloric acid (4:1) in place of ethanolmethanesulfonic acid,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan136 is obtained.

By using naloxone hydrochloric acid salt in place of naltrexonehydrochloric acid salt, and by using 2-trifluoromethylphenylhydrazine,2-ethoxycarbonylphenylhydrazine, 2-phenylphenylhydrazine,2-methylthiophenylhydrazine, 2-(2-hydroxyethyl)phenylhydrazine,2-(N-cyclopropylmethylsulfamoyl)phenylhydrazine,2-(N,N-dimethylsulfamoyl)phenylhydrazine, 2-sulfamoylphenylhydrazine,2-ethoxycarbonylmethylphenylhydrazine,2-(N-cyclopropylmethylcarbamoyl)phenylhydrazine,2-trifluoromethoxyphenylhydrazine, 2-iodophenylhydrazine,2-(N,N-dimethylamino)methylphenylhydrazine, 2-2-(N,N-dimethylamino)ethyl!phenylhydrazine,1-methyl-1-(2-methylthiophenyl)hydrazine,1-methyl-1-(2-phenylphenyl)hydrazine, 1-methyl-1- 2-2-(N,N-dimethylamino)ethyl)!phenyl!hydrazine or 1-methyl-2-(N,N-dimethylamino)methylphenyl!hydrazine as the phenylhydrazinederivative,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-trifluoromethyl-6,7-2',3'-indolomorphinan137,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan138,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-phenyl-6,7-2',3'-indolomorphinan139,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan140,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(2-hydroxyethyl)-6,7-2',3'-indolomorphinan141,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylsulfamoyl)-6,7-2',3'-indolomorphinan142,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylsulfamoyl)-6,7-2',3'-indolomorphinan143,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-sulfamoyl-6,7-2',3'-indolomorphinan144,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonylmethyl-6,7-2',3'-indolomorphinan145,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan146,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-trifluoromethoxy-6,7-2',3'-indolomorphinan147,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-iodo-6,7-2',3'-indolomorphinan148,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan149, 17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-2-(N,N-dimethylamino)ethyl!-6,7-2',3'-indolomorphinan 150,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-methylthio-6,7-2',3'-indolomorphinan151,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-phenyl-6,7-2',3'-indolomorphinan152, 17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-2-(N,N-dimethylamino)ethyl!-6,7-2',3'-indolomorphinan 153 and17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-1'-methyl-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan154 are obtained, respectively.

By using naloxone hydrochloric acid salt and 2-nitrophenylhydrazine inplace of naltrexone hydrochloric acid salt and2-trifluoromethylphenylhydrazine and by using acetic acid--12Nhydrochloric acid (4:1) in place of ethanol-methanesulfonic acid,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan155 is obtained.

119 methanesulfonic acid salt (yield 38%)

mp.>200° C. (decomposed). NMR (400 MHz, DMSO-d6); δ 0.44 (1H, m), 0.50(1H, m), 0.63 (1H, m), 0.74 (1H, m), 1.14 (1H, m), 1.31 (3H, t, J=6.8Hz), 1.85 (1H, m), 2.30 (3H, s), 2.57 (1H, d, J=16.1 Hz), 2.59 (1H, m),2.73 (1H, m), 2.94 (1H, m), 2.98 (1H, d, J=16.1 Hz), 3.12 (1H, m), 3.26(1H, dd, J=20.0, 6.8 Hz), 3.38 (1H, m), 3.45 (1H, d, J=20.0 Hz), 4.08(1H, br d , J=6.3 Hz), 4.43 (1H, dq, J=10.7, 6.8 Hz), 4.49 (1H, dq,J=10.7, 6.8 Hz), 5.79 (1H, s), 6.38 (1H, br s, OH), 6.60 (1H, d, J=8.3Hz), 6.64 (1H, d, J=8.3 Hz), 7.12 (1H, dd, J=7.8, 7.3 Hz), 7.68 (1H, brd, J=7.8 Hz), 7.81 (1H, dd, J=7.3, 1.0 Hz), 8.95 (1H, m, NH⁺), 9.25 (1H,br s, OH), 11.24 (1H, s, NH). IR (KBr) ν 3420, 1690, 1638, 1620, 1508,1466, 1435, 1290, 1207, 1166, 1116, 1044, 866, 756 cm⁻¹. Mass (negativeFAB); m/z 485 ((M-H)⁻). Elementary Analysis: C₂₉ H₃₀ N₂ O₅.CH₃ SO₃H.0.6H₂ O; Calcd.: C., 60.71; H, 5.98; N, 4.72; S, 5.40. Found: C.,60.56; H, 5.93; N, 4.74; S, 5.68.

120 methanesulfonic acid salt (yield 35%)

mp.>300° C. (decomposed, ether); NMR (400MHz, DMSO-d6); δ 0.45 (1H, m),0.50 (1H, m), 0.64 (1H, m), 0.74 (1H, m), 1.10 (1H, m), 1.83 (1H, br d,J=10.7 Hz), 2.30 (3H, s), 2.50 (1H, m), 2.56 (1H, d, J=16.1 Hz), 2.60(1H, m), 2.73 (1H, m), 2.94 (1H, m), 2.98 (1H, d, J=16.1 Hz), 3.10 (1H,br d, J=12.7 Hz), 3.24-3.34 (2H, m), 4.10 (1H, br d, J=6.8 Hz), 5.66(1H, s), 6.37 (1H, s), 6.60 (1H, d, J=8.3 Hz), 6.64 (1H, d, J=8.3 Hz),7.09 (1H, dd, J=7.3, 6.8 Hz), 7.15 (1H, dd, J=7.3, 1.5 Hz), 7.37 (1H,dd, J=6.8, 1.5 Hz), 7.45 (1H, t, J=7.3 Hz), 7.55 (2H, t, J=7.3 Hz), 7.63(2H, d, J=7.3 Hz), 8.93 (1H, br s), 9.20 (1H, s), 11.20 (1H, s). IR(KBr) ν 3400, 1682, 1506, 1464, 1323, 1278, 1149, 1044, 901, 768, 557cm⁻¹ Mass (FAB); m/z 491 ((M+H)⁺). Elementary Analysis: C₃₃ H₃₄ N₂ O₆S₁.0.1H₂ O; Calcd.: C., 67.35; H, 5.86; N, 4.76; S, 5.45. Found: C.,67.07; H, 6.02; N, 4.76; S, 5.49.

121 methanesulfonic acid salt (yield 61%)

mp.>205° C. (decomposed); NMR (400 MHz, DMSO-d6); δ 0.39-0.78 (4H, m),1.03-1.15 (1H, m), 1.84 (1H, br d, J=11.2 Hz), 2.33 (3H, s), 2.52(3H,s), 2.50-2.80 (3H, m), 2.87-3.02 (2H, m), 3.06-3.17 (1H, m), 3.25(1H, dd, J=19.5, 6.8 Hz), 3.30-3.48 (2H,m), 4.08 (1H, d, J=6.4 Hz), 5.67(1H, s), 6.35 (1H,br s), 6.59 (1H, d, J=7.8 Hz), 6.64 (1H, d, J=7.8 Hz),6.99 (1H, t,J=7.8 Hz), 7.11 (1H, d, J=7.8 Hz), 7.24 (1H, d, J=7.8 Hz),8.30 (1H, br s), 8.93 (1H, br s), 11.36 (1H, s). IR(KBr) ν 3420, 1620,1508, 1462, 1421, 1319, 1207, 1116, 783 cm⁻¹. Mass (FAB); m/z 461(M+H).⁺ Elementary Analysis: C₂₇ H₂₈ N₂ O₃ S.CH₃ SO₃ H.0.6H₂ O; Calcd.:C., 59.26; H, 5.90; N, 4.94; S, 11.30. Found: C., 59.23; H, 5.91; N,4.92; S, 11.45.

136 methanesulfonic acid salt (yield 24%)

mp.: 235° C. (decomposed); NMR (400 MHz, DMSO-d6); δ 0.45 (1H, m), 0.50(1H, m), 0.63 (1H, m), 0.74 (1H, m), 1.09 (1H, m), 1.87 (1H, br d ,J=10.7 Hz), 2.29 (3H, s), 2.58 (1H, d, J=16.6 Hz), 2.60 (1H, m), 2.75(1H, m), 2.95 (1H, m), 3.01 (1H, d, J=16.6 Hz), 3.13 (1H, m), 3.25 (1H,dd, J=20.0, 6.8 Hz), 3.40 (1H,m), 3.47 (1H, J=20.0 Hz), 4.10 (1H, d,J=6.8 Hz), 5.75 (1H, s), 6.44 (1H, s), 6.61 (1H, d, J=8.3 Hz), 6.65 (1H,d, J=8.3 Hz), 7.23(1H, dd, J=8.3, 7.8 Hz), 7.90 (1H, d, J=7.8 Hz), 8.14(1H, d, J=8.3 Hz), 8.96 (1H, br s), 9.26 (1H, br s), 12.17 (1H, s). IR(KBr) ν 3410, 1632, 1510, 1466, 1348, 1317, 1158, 1038, 741 cm⁻¹. Mass(FAB); m/z 458 ((M-H)⁻). Elementary Analysis: C₂₆ H₂₅ N₃ O₅.CH₃ SO₃H.0.8H₂ O; Calcd.: C., 56.89; H, 5.41; N, 7.37; S, 5.62. Found: C.,56.91; H, 5.58; N, 7.25; S, 5.60.

Example 4

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!pyrido 4,3-g!indole 156 ##STR17##

Using 1.34 g of naltrexone hydrochloric acid salt, 0.64 g of5-hydrazinoisoquinoline, 0.71 ml of methanesulfonic acid and 21 ml ofethanol, the reaction and purification as in Example 1 were carried outto obtain 1.53 g of methanesulfonic acid salt of the captioned compound(yield 64%).

156 methanesulfonic acid salt

mp.>280° C. (decomposed); NMR (400 MHz, DMSO-d6); δ 0.42-0.80 (4H, m),1.07-1.18 (1H, m), 1.90 (1H, br d, J=11.7 Hz), 2.36 (6H, s), 2.64-2.83(2H, m), 2.67 (1H, d, J=16.1 Hz), 2.95-3.05 (1H, m), 3.13-3.24 (1H, m),3.19 (1H, d, J=16.1 Hz), 3.29 (1H, dd, J=6.8, 20.0 Hz), 3.30-3.53 (2H,m), 3.50 (1H, d, J=20.0 Hz), 4.16 (1H, d, J=6.8 Hz), 5.92 (1H, s), 6.47(1H, br s), 6.64 (1H, d, J=8.3 Hz), 6.67 (1H, d, J=8.3 Hz), 7.97 (1H, d,J=8.8 Hz), 8.00 (1H, d, J=8.8 Hz), 8.75 (1H, d, J=6.8 Hz), 8.83 (1H, d,J=6.8 Hz), 9.00 (1H, br s), 9.32 (1H, br s), 9.74 (1H, s), 13.37 (1H,s). IR (KBr) ν 3400, 1638, 1388, 1330, 1199 ,1116, 1052, 785 cm⁻¹ Mass(FAB); m/z 466 ((M+H)⁺). Elementary Analysis: C₂₉ H₂₇ N₃ O₃.2.1CH₃ SO₃H.0.4H₂ O; Calcd.:C, 55.37; H, 5.41; N, 6.23; S, 9.98. Found :C, 55.54;H, 5.71; N, 6.32; S, 9.71.

By using 5-hydrazinoquinoline or 8-hydrazinoquinoline in place of5-hydrazinoisoquinoline,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-g!indole 157 and17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-g!indole 158 are obtained, respectively. By using6-hydrazinoquinoline in place of 5-hydrazinoisoquinoline,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!pyrido 3,2-e!indole 159 and17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!pyrido 2,3-f!indole 160 are obtained.

By using naloxone hydrochloric acid salt in place of naltrexonehydrochloric acid salt, and by using 5-hydrazinoisoquinoline,5-hydrazinoquinoline or 8-hydrazinoquinoline as the hydrazinederivative, 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!pyrido 4,3-g!indole 161,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!pyrido2,3-g!indole 163 and17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!pyrido3,2-g!indole 164 are obtained, respectively. By using6-hydrazinoquinoline as the hydrazine derivative,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!pyrido3,2-e!indole 165 and17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano 6,7-b!pyrido2,3-f!indole 166 are obtained.

Example 5

17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 2 ##STR18##

Using 966 mg of naltrexone hydrochloric acid salt, 770 mg of1-hydrazino-5,6,7,8-tetrahydronaphthalene, 0.46 ml of methanesulfonicacid and 15 ml of ethanol, the reaction and purification as in Example 1were carried out to obtain 525 mg of methanesulfonic acid salt of thecaptioned compound (yield 32%).

2 methanesulfonic acid salt

mp.>235° C. (decomposed); NMR (500 MHz, CDCl3, data for free base); δ0.13-0.20 (2H, m), 0.53-0.61 (2H, m), 0.85-0.93 (1H, m), 1.77-1.89(5H,m), 2.30 (1H, dt, J=3.5, 12.5 Hz), 2.38-2.47 (2H, m), 2.46 (1H, dd,J=6.4, 12.5 Hz), 2.60 (1H, dd, J=1.1, 15.7 Hz), 2.67-2.86 (6H, m), 2.86(1H, d, J=15.6 Hz), 3.12 (1H, d, J=18.3 Hz), 3.36 (1H, d, J=6.6 Hz),5.04 (2H, br s), 5.71 (1H, s), 6.53 (1H, d, J=8.1 Hz), 6.60 (1H, d,J=8.1 Hz), 6.74 (1H, d, J=8.1 Hz), 7.14 (1H, d, J=8.1 Hz), 8.06 (1H, s).IR(KBr) ν 3400, 1510, 1460, 1207, 1048 cm⁻¹ Mass (EI); m/z 468 (M⁺).Elementary Analysis: C₃₀ H₃₂ N₂ O₃.CH₃ SO₃ H.0.6H₂ O; Calcd.:C, 64.70;H, 6.51; N, 4.87; S, 5.57. Found :C, 64.33; H, 6.54; N, 4.95; S, 5.83.

By using 1-hydrazino-5-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-6-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-7-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-8-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-5-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-6-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-7-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-8-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-hyclrazino-5-sulfamoyl-5,6,7,8-tetrahydronaphthalene,1-hyclrazino-6-sulfamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-7-sulfamoyl-5,6,7,8-tetrahydronaphthalene or1-hydrazino-8-sulfamoyl-5,6,7,8-tetrahydronaphthalene in place of1-hydrazino-5,6,7,3-tetrahydronaphthalene,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 401,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 402,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 403,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 404,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 405,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 406,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 407,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 408,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 409,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 410,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 411 and17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 412 are obtained, respectively.

By using 2-hydrazino-5,6,7,8-tetrahydronaphthalene in place of1-hydrazino-5,6,7,8-tetrahydronaphthalene,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole 413 and17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 414 are obtained. By using 4-hydrazinoindanin place of 1-hydrazino-5,6,7,8-tetrahydronaphthalene,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 415 is obtained. By using 5-hydrazinoindanin place of 1-hydrazino-5,6,7,8-tetrahydronaphthalene,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 416 and17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole 417 are obtained. By using1-hydrazino-6,7,8,9-tetrahydro-5H-benzocycloheptene in place of1-hydrazino-5,6,7,8-tetrahydronaphthalene,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 418 is obtained. By using2-hydrazino-6,7,8,9-tetrahydro-5H-benzocycloheptene in place of1-hydrazino-5,6,7,8-tetrahydronaphthalene,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole 419 and17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 420 are obtained. By using1-hydrazino-5,6,7,8,9,10-hexahydrobenzocyclooctene in place of1-hydrazino-5,6,7,8-tetrahydronaphthalene,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 421 is obtained. By using2-hydrazino-5,6,7,8,9,10-hexahydrobenzocyclooctene in place of1-hydrazino-5,6,7,8-tetrahydronaphthalene,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 422 and17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 423 are obtained.

By using naloxone hydrochloric acid salt in place of naltrexonehydrochloric acid salt and by using1-hydrazino-5,6,7,8-tetrahydronaphthalene,1-hydrazino-5-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-6-ethoxycarbonyl.-5,6,7,8-tetrahydronaphthalene,1-hydrazino-7-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-hycdrazino-8-ethoxycarbonyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-5-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-6-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-7-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-8-carbamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-5-sulfamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-6-sulfamoyl-5,6,7,8-tetrahydronaphthalene,1-hydrazino-7-sulfamoyl-5,6,7,8-tetrahydronaphthalene or1-hydrazino-8-sulfamoyl-5,6,7,8-tetrahydronaphthalene as the hydrazinederivative, 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 162,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 424,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 425,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 426,17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 427,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 428,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 429,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 430,17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 431,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 432,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 433,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 434 and17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 435 are obtained, respectively. By using2-hydrazino-5,6,7,8-tetrahydronaphthalene as the hydrazine derivative,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole 436 and17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 437 are obtained. By using 4-hydrazinoindanas the hydrazine derivative,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 438 is obtained. By using 5-hydrazinoindanas the hydrazine derivative,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 439 and17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole 440 are obtained. By using1-hydrazino-6,7,8,9-tetrahydro-5H-benzocycloheptene as the hydrazinederivative, 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 441 is obtained. By using2-hydrazino-6,7,8,9-tetrahydro-5H-benzocycloheptene as the hydrazinederivative, 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole 442 and17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 443 are obtained. By using1-hydrazino-5,6,7,8,9,10-hexahydrobenzocyclooctene as the hydrazinederivative, 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 444 is obtained. By using2-hydrazino-5,6,7,8,9,10-hexahydrobenzocyclooctene as the hydrazinederivative, 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 445 and17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 446 are obtained. Example 6

17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-amino-6,7-2',3'-indolomorphinan167 ##STR19##

In 20 ml of ethanol, 1.00 g of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan136 and 3.50 g of stannous chloride dihydrate were dissolved and theresulting mixture was heated at 70° C. for 3 hours under stirring. Afterleaving the reaction mixture to cool to room temperature, 2N aqueoussodium hydroxide solution was added while cooling the mixture in icedwater to neutralize the mixture, and the generated precipitates wereremoved by filtration. The filtrate was extracted with ethyl acetate andthe combined organic layers were washed with saturated saline. Afterdrying and concentration, obtained unpurified captioned compound wasconverted to 680 mg of dihydrochloride (yield 62%).

167 dihydrochloride Mass (FAB); m/z 430 ((M+H)⁺).

By using17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-nitro-6,7-2',3'-indolomorphinan79,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan78,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan155,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-nitro-6,7-2',3'-indolomorphinan117 or17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan116 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan136,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-amino-6,7-2',3'-indolomorphinan168,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-amino-6,7-2',3'-indolomorphinan169, 17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-amino-6,7-2',3'-indolomorphinan 170,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-amino-6,7-2',3'-indolomorphinan171 and17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan172 are obtained, respectively.

168 dihydrochloride Mass (FAB); m/z 430 ((M+H)⁺).

169 dihydrochloride Mass (FAB); m/z 430 ((M+H)⁺).

Example 7

17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan173 ##STR20##

In 20 ml of water, 600 mg of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-amino-6,7-2',3'-indolomorphinan167-dihydrochloride was dissolved and the solution was cooled in icedwater. To this solution, a solution containing 95 μl of thiophosgene in10 ml of chloroform was added dropwise and the mixture was warmed toroom temperature, followed by stirring the mixture for 5 hours at roomtemperature. The mixture was neutralized by adding saturated aqueoussodium hydrogen carbonate solution while cooling the mixture in icedwater and chloroform-methanol (3:1) was added to dissolve insolublematters, followed by separating the generated two layers. The resultantwas extracted twice with 20 ml of chloroform-methanol (3:1) and thecombined organic layers were washed with saturated saline. After dryingand concentration, the obtained residue was purified by columnchromatography silica gel; chloroform:methanol (95:5)! to obtain thecaptioned compound which was then converted to 353 mg of methanesulfonic acid salt (yield 52%).

173 methanesulfonic acid salt

mp.: 170° C. (decomposed); NMR (500 MHz, DMSO-d6); δ 0.44 (1H, m), 0.50(1H, m), 0.63 (1H, m), 0.73 (1H, m), 1.09 (1H, m), 1.85 (1H, br d,J=11.0 Hz), 2.30 (3H, s), 2.54 (1H, d, J=15.9 Hz), 2.60 (1H, m),2.73(1H, m), 2.94 (1H, m), 2.95 (1H, d, J=15.9 Hz), 3.11 (1H, m), 3.25 (1H,m), 3.38 (1H,m), 3.44 (1H, J=20.1 Hz), 4.08 (1H, d, J=6.7 Hz), 5.68 (1H,s), 6.37 (1H, s), 6.60 (1H, d, J=7.9 Hz), 6.65 (1H, d, J=7.9 Hz),7.03(1H, t, J=7.9 Hz), 7.30 (1H, d, J=7.9 Hz), 7.40 (1H, d, J=7.9 Hz),8.93 (1H, br s), 9.24 (1H, br s), 12.14 (1H, s). IR (KBr) ν 3410, 2122,1462, 1323, 1195, 1048, 785 cm⁻¹. Mass (FAB); m/z 472 ((M+H)⁺).Elementary Analysis: C₂₇ H₂₅ N₃ O₃ S.CH₃ SO₃ H.1.3H₂ O; Calcd.:C, 56.90;H, 5.39; N, 7.11; S, 10.85. Found :C, 56.89; H, 5.54; N, 7.04; S, 10.83.

By using17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-amino-6,7-2',3'-indolomorphinan168-dihydrochloride,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-amino-6,7-2',3'-indolomorphinan169.dihydrochloride,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-amino-6,7-2',3'-indolomorphinan170,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-amino-6,7-2',3'-indolomorphinan171 or17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-amino-6,7-2',3'-indolomorphinan172 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-amino-6,7-2',3'-indolomorphinan167.dihydrochloride,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan174,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan175,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan176,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan177, and17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan178 are obtained, respectively.

174 methanesulfonic acid salt (yield 23%)

mp.: 200° C. (decomposed); NMR (400 MHz, DMSO-d6); δ 0.44 (1H, m), 0.49(1H, m), 0.63 (1H.sub., m), 0.73 (1H, m), 1.09 (1H, m), 1.82 (1H, br d,J=11.7 Hz), 2.30 (3H, s), 2.52-2.64 (2H, m), 2.71 (1H, m), 2.93 (1H, m),2.95 (1H, d, J=16.1 Hz), 3.11 (1H, m), 3.25 (1H, dd, J=20.0, 6.8 Hz),3.38 (1H,m), 3.44 (1H, J=20.0 Hz), 4.07 (1H, d, J=6.4 Hz), 5.69 (1H, s),6.36 (1H, s), 6.60 (1H, d, J=7.8 Hz), 6.64 (1H, d, J=7.3 Hz), 7.04(1H,dd, J=8.3, 1.5 Hz), 7.41 (1H, d, J=8.3 Hz), 7.44 (1H, d, J=1.5 Hz), 8.93(1H, br s), 9.24 (1H, br s), 11.69 (1H, s). IR (KBr) ν 3380, 2122, 1462,1332, 1195, 1116, 1048, 855, 799, 785 cm⁻¹. Mass (FAB); m/z 472((M+H)⁺). Elementary Analysis: C₂₇ H₂₅ N₃ O₃ S.CH₃ SO₃ H.0.7H₂ O;Calcd.:C, 57.96; H, 5.28; N, 7.24; S, 11.05. Found :C, 57.94; H, 5.59;N, 7.20; S, 10.97.

175 methanesulfonic acid salt (yield 46%)

mp.: 175° C. (decomposed); NMR (500 MHz, DMSO-d6); δ 0.44 (1H, m), 0.52(1H, m), 0.65 (1H, m), 0.72 (1H, m), 1.16 (1H, m), 1.84 (1H, br d,J=10.4 Hz), 2.29 (3H, s), 2.61 (1H, m), 2.67 (1H, (d, J=15.9 Hz), 2.73(1H, m), 2.90 (1H, m), , 3.13 (1H, m), 3.23 (1H, d, J=16.5 Hz), 3.28(1H,m), 3.45 (1H, m), 3.47 (1H, d, J=19.5 Hz), 4.04 (1H, d, J=6.7 Hz),5.70 (1H, s), 6.40 (1H, s), 6.62 (1H, d, J=8.5 Hz), 6.65 (1H, d, J=8.5Hz), 7.09(1H, d, J=7.9 Hz), 7.14 (1H, t, J=7.9 Hz), 7.39 (1H, d, J=7.9Hz), 8.95 (1H, br s), 9.24 (1H, br s), 11.83 (1H, s). IR (KBr) ν 3390,2120, 1462, 1332, 1199, 1116, 1050, 783 cm⁻¹. Mass (FAB); m/z 472((M+H)⁺). Elementary Analysis: C₂₇ H₂₅ N₃ O₃ S.CH₃ SO₃ H.0.5H₂ O;Calcd.:C, 58.32; H, 5.24; N, 7.28; S, 11.12. Found :C, 58.19; H, 5.34;N, 7.23; S, 11.22.

Example 8

3-(tert-butyldimethylsiloxy)-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan179 ##STR21##

In 2.6 ml of anhydrous DMF, 379.1 mg of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan7 was dissolved. To this solution, 204.4 mg of imidazole and 228.6 mg oftert-butylchlorodimethylsilane were added and the resulting mixture wasstirred at room temperature for 1 hour. To the reaction mixture, 30 mlof water was added and the resultant was extracted with ether (3×30 ml).The organic layers were combined, dried and concentrated to obtain 536mg of an oily product. The obtained oily product was purified by columnchromatography silica gel; hexane-ethyl acetate-methanol (7:7:1)! toobtain 446.7 mg (yield 96%) of the captioned compound. A part of theobtained crude crystals were recrystallized from ethyl acetate to obtaincrystals in the form of plate (recrystallization yield 75%).

mp.: 174°-184° C. (ethyl acetate); NMR (400 MHz, CDCl3); δ -0.01 (3H,s), 0.02 (3H, s), 0.17 (2H, m), 0.27 (2H, m), 0.52-0.61(4H, m), 0.87(9H, s), 0.89 (1H, m), 1.06 (1H, m), 1.78 (1H, m), 2.27-2.48 (4H, m),2.64 (1H, br d, J=15.6 Hz), 2.75 (1H, m), 2.81 (1H, dd, J=19.0, 6.3 Hz),2.90 (1H, d, 15.6 Hz), 3.14 (1H, d, 19.0 Hz), 3.30 (2H, m), 3.36 (1H,m), 4.95 (1H, br s, OH), 5.60 (1H, s), 6.20 (1H, m, NH), 6.53 (1H, d,J=8.3 Hz), 6.57 (1H, d, J=8.3 Hz), 7.19 (1H, d, J=8.3 Hz), 7.56 (1H, dd,J=8.3, 2.0 Hz), 7.84 (1H, br s), 8.25 (1H, s, NH). IR (KBr) ν 3400,3080, 1638, 1620, 1522, 1497, 1473, 1446, 1336, 1259, 1166, 1035, 955,853, 801, 783 cm⁻¹. Mass (EI); m/z 625 (M⁺).

Example 9

17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylamino)methyl-6,7-2',3'-indolomorphinan180 ##STR22##

In 4.5 ml of anhydrous THF, 403.3 mg of3-(tert-butyldimethylsiloxy)-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan179 was dissolved under argon gas flow. To this solution, 1.7 ml of 2.0Mdiborane dimethylsulfide complex solution in anhydrous THF was addeddropwise at 0° C. and the resulting mixture was heated to reflux for 2.7hours. After cooling the reaction mixture to 0° C., 4 ml of 6Nhydrochloric acid was added and the resulting mixture was again heatedto reflux for 1 hour. After cooling the reaction mixture to 0° C., 40 mlof saturated aqueous sodium hydrogen carbonate solution was added tomake the mixture basic, and the resultant was extracted withchloroform-methanol (3:1) (3×20 ml). The organic layers were combinedand dried to condense the extract to obtain 403 mg of an oily product.This oily product was purified by column chromatography 1 silica gel;chloroform-methanol saturated with ammonia (20:1→15:1); 2 silica gel forflush column chromatography; chloroform-methanol saturated with ammonia(25:1→15:1); 3 SEPHADEX gel; methanol! to obtain 165.2 mg (yield 47%,two steps) of methanesulfonic acid salt of free base of the captionedcompound. The obtained free base was dissolved in methanol and 0.045 mlof methanesulfonic acid was added thereto. Excess ethyl acetate was thenadded to precipitate the product to obtain 224.1 mg (yield 46%, twosteps) of the captioned compound.

180 methanesulfonic acid salt mp.>190° C. (decomposed). NMR (400 MHz,DMSO-d6); δ 0.30 (2H, mn), 0.44 (1H, mn), 0.51 (1H, m), 0.55 (2H, n),0.64 (1H, mn), 0.73 (1H, In), 1.02 (1H, mn), 1.12 (1H, m), 1.83 (1H,mn), 2.32 (6H, s), 2.48-2.78 (5H, m), 2.94 (1H, d, J=16.1 Hz), 2.95 (1H,in), 3.14 (1H, mn), 3.24 (1H, dd, J=20.0, 6.8 Hz), 3.34 (1H, mn), 3.45(1H, d, J=20.0 Hz), 4.08 (1H, br d, J=6.3 Hz), 4.15-4.21 (2H, in), 5.70(1H, s), 6.34 (1H,br s, OH), 6.59 (1H, d, J=8.3 Hz), 6.63 (1H, d, J=8.3Hz), 7.24 (1H, dd, J=8.3, 1.5 Hz), 7.42 (1H, d, J=8.3 Hz), 7.47 (1H, brs), 8.73 (2H, in, NH2+), 8.91 (1H, in, NH⁺), 9.24 (1H, br s, OH), 11.51(1H, s, NH). IR (KBr) ν 3386, 1638, 1626, 1462, 1328, 1197, 1116, 1060,866, 785 cm⁻¹. Mass (FAB); m/z 498 ((M+H)⁺). Elementary Analysis: C₃₁H₃₅ N₃ O₃. 2CH₃ SO₃ H.1.5H₂ O; Calcd.:C, 55.29; H, 6.47; N, 5.86; S,8.95. Found :C, 55.49; H, 6.37; N, 5.60; S, 8.79.

In accordance with Examples 7 and 8, by using17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan46,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan47,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan127,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan84,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan26,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan85 or17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan146 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan7,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylamino)methyl-6,7-2',3'-indolomorphinan181,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylamino)methyl-6,7-2',3'-indolomorphinan182,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylamino)methyl-6,7-2',3'-indolomorphinan183,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylamino)methyl-6,7-2',3'-indolomorphinan184,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylamino)methyl-6,7-2',3'-indolomorphinan185,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylamino)methyl-6,7-2',3'-indolomorphinan186, and17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylamino)methyl-6,7-2',3'-indolomorphinan187 are obtained, respectively.

Example 10

17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan188 ##STR23##

In 14 ml of acetic acid, 459.6 mg of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43 was dissolved. To this solution, 0.57 ml of 30% aqueous hydrogenperoxide solution was added and the resulting mixture was stirred at 50°C. for 4 hours. After cooling the reaction mixture to room temperature,10 ml of aqueous saturated sodium thiosulfate solution was added to themixture and the mixture was stirred for 10 minutes, followed byconcentration of the mixture. To the residue, 15 ml of chloroform and 15ml of 3N aqueous sodium hydroxide solution were added and generatedlayers were separated. The aqueous layer was further extracted twicewith 10 ml of chloroform. The obtained organic layers were dried overanhydrous sodium sulfate and then concentrated. The obtained residue waspurified by column chromatography silica gel; chloroform saturated withammonia/methanol (15:1)! to obtain 310.2 mg of the captioned compound.The thus obtained compound was dissolved in 4 ml of methanol and 41 μlof methanesulfonic acid was added thereto, followed by concentration ofthe mixture. The obtained residue was purified by column chromatographySEPHADEX-LH-20; methanol! and excess ether was added. The solids werecollected by filtration and washed to obtain 210 mg (yield 38%) of whitemethanesulfonic acid salt. 188 methanesulfonic acid salt

mp.: 255°-260° C. (decomposed); NMR(free, 400 MHz, CDCl3); δ 0.10-0.22(2H, m), 0.50-0.62 (2H, m), 0.82-0.93 (1H, m), 1.80 (1H,br d, J=11.2Hz), 1.95 (1H, br s), 2.25-2.50 (5H, m), 2.64 (1H, d, J=16.1 Hz),2.72-2.83 (1H, m), 2.92 (3H, s), 2.89-3,00 (1H, m), 3.12 (1H, d, J=18.6Hz), 3.32 (1H, d, J=6.3 Hz), 5.64 (1H, s), 6.55 (1H, br d, J=8.3 Hz),6.68 (1H, d, J=8.1 Hz), 6.84 (1H, br d, J=8.3 Hz), 9.24 (1H, br s). IR(KBr) ν 3450, 1510, 1460, 1294, 1210, 1141, 1122, 1048, 779 cm⁻¹ Mass(FAB); m/z 493 ((M+H)⁺). Elementary Analysis: C₂₇ H₂₈ N₂ O₅ S.CH₃ SO₃H.0.6H₂ O; Calcd.:C, 56.10; H, 5.58; N, 4.67; S, 10.70. Found :C, 56.19;H, 5.76; N, 4.61; S, 10.32.

By using17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan42,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylthio-6,7-2',3'-indolomorphinan12,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan121,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan80,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylthio-6,7-2',3'-indolomorphinan31,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan81 or17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan140 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan189,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan6,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan190,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan191,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan25,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan192 and17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan193 are obtained, respectively.

190 methanesulfonic acid salt (yield 25%)

mp.>215° C. (decomposed); NMR (400 MHz, DMSO-d6); δ 0.40-0.54 (2H, m),0.59-0.77 (2H, m), 1.04-1.17 (1H, m), 1.86 (1H,br d, J=10.7 Hz), 2.30(3H, s), 2.50-2.79 (2H, m), 2.57 (1H, d, J=16.1 Hz), 2.90-3.00 (1H, m),3.00 (1H, d, J=16.1 Hz), 3.06-3.50 (3H, m), 3.31 (3H, s), 4.09 (1H, d,J=6.4 Hz), 5.75 (1H, s), 6.41 (1H,s), 6.61 (1H, d, J=7.8 Hz), 6.65 (1H,d, J=7.8 Hz), 7.22 (1H, t, J=7.6 Hz), 7.65 (1H, dd, J=7.3, 1.0 Hz), 7.76(1H, d, J=7.8 Hz), 8.95 (1H, br s), 9.27 (1H, s), 11.66 (1H, s). IR(KBr) ν 3420, 1620, 1462, 1299, 1205, 1125, 1048 cm⁻¹ Mass (FAB); m/z493 (M+H)⁺ ; Elementary Analysis: C₂₇ H₂₈ N₂ O₅ S.CH₃ SO₃ H.0.8H₂ O;Calcd.:C, 55.76; H, 5.62; N, 4.64; S, 10.63. Found :C, 55.78; H, 5.65;N, 4.55; S, 10.56.

Example 11

17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan194 ##STR24##

In 20 ml of methanol, 600 mg of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan77 was dissolved and the solution was cooled to 0° C. To this solution,diazomethane solution in ether was added dropwise until the startingmaterial disappeared. The reaction was monitored by TLC. Aftercompletion of the reaction, the solvent was evaporated and the obtainedcrude crystals were recrystallized from methanol to obtain 515 mg of thecaptioned compound (yield 83%). Four hundred fifty milligrams of thisproduct was converted to methanesulfonic acid salt and the salt wasrecovered by filtration after adding ether to obtain 502 mg ofmethanesulfonic acid salt of the captioned compound.

194 methanesulfonic acid salt

mp.: 220°˜227° C. (decomposed); NMR(free, 400 MHz, CDCL3); δ 0.15-0.23(2H,m), 0.54-0.64 (2H, m), 0.93 (1H, m), 1.82 (1H, m), 2.32 (1H, m),2.37-2.52 (3H, m), 2.64 (1H, d, J=15.1 Hz) 2.74-2.90 (2H, m), 2.92 (1H,d, J=15.1 Hz), 3.17 (1H, d, J=18.6 Hz), 3.43 (1H, m), 3.77 (3H, m), 3.90(3H, m), 5.05 (1H, br s), 5.69 (1H, s), 6.64 (1H, d, J=8.3 Hz), 6.67(1H, d, J=8.3 Hz), 7.38 (1H, d, J=8.3 Hz), 7.69 (1H, dd, J=8.3, 1.5 Hz),7.97 (1H, s), 8.60 (1H, br s). Mass (EI); m/z 486 (M⁺) ElementaryAnalysis: C₂₉ H₃₀ N₂ O₅.CH₃ SO₃ H.0.8H₂ O; Calcd.:C, 60.35; H, 6.01; N,4.69; S, 5.37. Found :C, 60.23; H, 6.30; N, 4.72; S, 5.38.

By using17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan76,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan3,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan119,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan46,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan7,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan47,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan127,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-cyano-6,7-2',3'-indolomorphinan52,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-cyano-6,7-2',3'-indolomorphinan8,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-cyano-6,7-2',3'-indolomorphinan53,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan42,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5,-methylthio-6,7-2',3'-indolomorphinan12,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan121,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4,-methylsulfonyl-6,7-2',3'-indolomorphinan189,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan6,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan188,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7,-methylsulfonyl-6,7-2',3'-indolomorphinan190, 17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 64,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 9,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 65,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 131,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan66,17-cyclopropylmethyl-6,7-didehycdro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan10,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan67,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan130,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan175,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan174,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan173,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan78,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-nitro-6,7-2',3'-indolomorphinan79,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan136,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan114,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan22,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan115,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan138,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan84,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan26,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan85,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan146,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-cyano-6,7-2',3'-indolomorphinan90,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-cyano-6,7-2',3'-indolomorphinan27,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-cyano-6,7-2',3'-indolomorphinan91, 17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan 80,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylthio-6,7-2',3'-indolomorphinan31,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan81,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan140,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan191, 17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5-methylsulfonyl-6,7-2',3'-indolomorphinan 25,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan192,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan193, 17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 102,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 28,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 103,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 150,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan104,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan29,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan105,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylaminno)methyl-6,7-2',3'-indolomorphinan149,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan178,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan177,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan176,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan116,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-nitro-6,7-2',3'-indolomorphinan117 or17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan155 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan77,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan195,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hyclroxy-3-methoxy-5'-ethoxycarbonyl-6,7-2',3'-inciolomorphinan196,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan197,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan198,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan199,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan200,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan201,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-cyano-6,7-2',3'-indolomorphinan202,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5¹-cyano-6,7-2',3'-indolomorphinan 203,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-cyano-6,7-2',3'-indolomorphinan204,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-methylthio-6,7-2',3'-indolomorphinan205, 17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy3-methoxy-5'-methylthio-6,7-2',3'-indolomorphinan 206,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-methylthio-6,7-2',3'-indolomorphinan207,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-methylthio-6,7-2',3'-indolomorphinan208,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan209,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan210,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan211,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan212,17-cyclopropylmethyl-6,7-didehyciro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 213,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 214,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 215,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 216,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan217,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan218,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan219,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan220,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan221,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan222,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan223,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-nitro-6,7-2',3'-indolomorphinan224,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-nitro-6,7-2',3'-indolomorphinan225,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-nitro-6,7-2',3'-indolomorphinan226,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan227,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan228,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan229,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan230,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan231,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan232,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan233,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan234,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-cyano-6,7-2',3'-indolomorphinan235,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-cyano-6,7-2',3'-indolomorphinan236,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-cyano-6,7-2',3'-indolomorphinan237,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-methylthio-6,7-2',3'-indolomorphinan238,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-methylthio-6,7-2',3'-indolomorphinan239,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-methylthio-6,7-2',3'-indolomorphinan240,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-methylthio-6,7-2',3'-indolomorphinan241,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan242,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan243,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan244,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan245, 17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 246,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 247,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 248,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 249,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan250,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan251,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan252,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan253,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan254,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6,-isothiocyanato-6,7-2',3'-indolomorphinan255,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan256,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-4'-nitro-6,7-2',3'-indolomorphinan257,17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-nitro-6,7-2',3'-indolomorphinan258 and17-allyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-nitro-6,7-2',3'-indolomorphinan259 are obtained, respectively.

By using17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 2,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 401,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 402,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 403,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 404,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 405,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 406,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 407,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 408,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 409,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 410,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 411 or17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 412 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan77,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 447,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6'),-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 448,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 449,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 450,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 451,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 452,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 453,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 454,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 455,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 456,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 457,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 458 and17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 459 are obtained, respectively.

By using17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole 413,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 414,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 415,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 416,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole 417,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 418,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole 419,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 420,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 421,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 422 or17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 423 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan77,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole 460,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 461,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 462,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 463,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6₁57-didehydromorphinano 6,7-b!cyclopenteno f!indole 464,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 465,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano 6,7-b!cyclohepteno e!indole 466,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano 6,7-b!cyclohepteno f!indole 467,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano 6,7-b!cycloocteno g!indole 468,17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano 6,7-b!cyclohepteno e!indole 469 and17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 470 are obtained, respectively.

By using 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 162,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 424,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 425,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 426,17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 427,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 428,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 429,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 430,17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 431,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 432,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 433,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 434 or17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 435 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan77, 17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 471,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-ethoxycarbonyl-6,7-didehydro:morphinano6,7-b!cyclohexeno g!indole 472,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 473,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 474,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 475,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 476,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 477,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 478,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 479,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 480,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 481,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 482 and17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 483 are obtained, respectively.

By using 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole 436,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 437,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 438,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 439,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole 440,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 441,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole 442,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 443,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 444,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 445 or17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 446 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan77, 17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole 484,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 485,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 486,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 487,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole 488,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 489,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole 490,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 491,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 492,17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 493 and17-allyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 494 are obtained, respectively.

Example 12

3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-methylthio-6,7-2',3'-indolomorphinan##STR25##

In 5 ml of pyridine, 500 mg of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43 hydrochloric acid salt was dissolved and 0.20 ml of acetic anhydridewas added to the solution, followed by stirring the mixture at roomtemperature for 10 minutes. The reaction mixture was concentrated todryness to obtain 540 mg of hydrochloric acid salt of the captionedcompound.

260 hydrochloric acid salt

IR(KBr); ν 1754 cm⁻¹. Mass (FAB); m/z 503 (M+H)⁺

By using17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan42,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5,-methylthio-6,7-2',3'-indolomorphinan12,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan121,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan76,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan3,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan77,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan119,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan46,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan7,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan47,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan127,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-cyano-6,7-2',3'-indolomorphinan52,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-cyano-6,7-2',3'-indolomorphinan8,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-cyano-6,7-2',3'-indolomorphinan53,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan189,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan6,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan188,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan190, 17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 64,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 9,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 65,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 131,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan66,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan10,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan67,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan130,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan175,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan174,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan173,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan78,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-nitro-6,7-2',3'-indolomorphinan79,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan136,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan114,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan22,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan115,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan138,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan84,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan26,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan85,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan146,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-cyano-6,7-2',3'-indolomorphinan90,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-cyano-6,7-2',3'-indolomorphinan27,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-cyano-6,7-2',3'-indolomorphinan91,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan80,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylthio-6,7-2',3'-indolomorphinan31,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan81,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan140,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan191,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan25,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan192,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan193, 17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 102,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 28,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 103,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 150,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan104,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan29,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan105,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylamnino)methyl-6,7-2',3'-indolomorphinan149,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan178,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan177,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan176,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan116,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-nitro-6,7-2',3'-indolomorphinan117 or17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan155 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-methylthio-6,7-2',3'-indolomorphinan261,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-methylthio-6,7-2',3'-indolomorphinan262,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-methylthio-6,7-2',3'-indolomorphinan263,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan264,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan265,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan266,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan267,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan268,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan269,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan270,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan271,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-cyano-6,7-2',3'-indolomorphinan272,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-cyano-6,7-2',3'-indolomorphinan273,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-cyano-6,7-2',3'-indolomorphinan274,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan275,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan276,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan277,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan278,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 279,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 280,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 281,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 282,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan283,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan284,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hyciroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan285,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan286,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan287,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan288,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan289,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-nitro-6,7-2',3'-indolomorphinan290,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-nitro-6,7-2',3'-indolomorphinan291,3-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-nitro-6,7-2',3'-indolomorphinan292,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan293,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan294,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan295,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan296,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan297,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan298,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan299,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-(N-cyclopropylimethylcarbamoyl)-6,7-2',3'-indolomorphinan300,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-cyano-6,7-2',3'-indolomorphinan301,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-cyano-6,7-2',3'-indolomorphinan302,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-cyano-6,7-2',3'-indolomorphinan303,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-methylthio-6,7-2',3'-indolomorphinan304,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-methylthio-6,7-2',3'-indolomorphinan305,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-methylthio-6,7-2',3'-indolomorphinan306,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-methylthio-6,7-2',3'-indolomorphinan307,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan308,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan309,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan310,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan311, 17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 312,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 313,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 314,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 315,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan316,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan317,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan318,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan319,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan320,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan321,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan322,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-4'-nitro-6,7-2',3'-indolomorphinan323,17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-6'-nitro-6,7-2',3'-indolomorphinan324 and17-allyl-3-acetoxy-6,7-didehydro-4,5α-epoxy-14β-hydroxy-7'-nitro-6,7-2',3'-indolomorphinan325 are obtained, respectively.

By using17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 2,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-ethoxycarbonyl-6,7-didehydromorphinano 6,7-b!cyclohexeno g!indole 401,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 402,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 403,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 404,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 405,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 406,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 407,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 408,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 409,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-sulfamoyl-6,7-didehydromorphinano(6,7-b!cyclohexenog!indole 410,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 411 or17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 412 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 495,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 496,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 497,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 498,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-9'-ethoxycarbonyl-6,7-didehydroinorphinano6,7-b!cyclohexeno g!indole 499,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 500,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 501,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 502,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 503,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 504,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 505,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 506 and3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 507 are obtained, respectively.

By using17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole 413,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 414,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 415,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 416,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole 417,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 418,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole 419,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 420,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 421,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 422 or17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 423 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole 508,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 509,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 510,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 511,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole 512,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehyciromorphinano6,7-b!cyclohepteno g!indole 513,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole 514,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 515,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 516,3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 517 and3-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 518 are obtained, respectively.

By using 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 162,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 424,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 425,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 426,17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 427,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 428,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 429,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 430,17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 431,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 432,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 433,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 434 or17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 435 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43, 3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 519,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 520,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 521,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 522,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 523,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 524,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 525,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 526,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 527,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 528,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 529,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 530 and3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 531 are obtained, respectively.

By using 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorpliinano6,7-b!cyclohexeno e!indole 436,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 437,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 438,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 439,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole 440,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 441,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole 442,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 443,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 444,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 445 or17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 446 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6,-methylthio-6,7-2',3'-indolomorphinan43, 3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole 532,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 533,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 534,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 535,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole 536,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 537,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole 538,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 539,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 540,3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 541 and3-acetoxy-17-allyl-4,5α-epoxy-14β-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 542 are obtained, respectively.

Example 13

17-cyclopropylmethyl-3,14β-diacetoxy-6,7-didehydro-4,5α-epoxy-6'-methylthio-6,7-2',3'-indolomorphinan326 ##STR26##

In 50 ml of acetic anhydride, 1.00 g of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43 was dissolved and the solution was heated to reflux for 1 hour. Aftercooling the mixture to room temperature, the solvent was evaporated toobtain 1.29 g of unpurified captioned compound.

IR(KBr); ν 1760, 1727 cm⁻¹.

Example 14

14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-methylthio-6,7-2',3'-indolomorphinan327 ##STR27##

The 1.29 g of17-cyclopropylmethyl-3,14β-diacetoxy-6,7-didehydro-4,5α-epoxy-6'-methylthio-6,7-2',3'-indolomorphinan326 obtained in Example 13 was dissolved in 24 ml of 4% sulfuric acidand 24 ml of acetic acid, and the resulting solution was stirred at roomtemperature for 4 days. To the solution, 10% sodium hydroxide solutionwas added to make the solution basic and the resultant was extractedthree times with 50 ml of chloroform. The organic layers were combinedand washed with saturated saline, followed by drying and concentration.The obtained residue was purified by column chromatography silica gel;chloroform-chloroform/methanol (99:1)! to obtain 612 mg of the captionedcompound. The obtained compound was suspended in methanol andmethanesulfonic acid was added to the suspension to convert the compoundto methanesulfonic acid salt. The salt was purified by columnchromatograph SEPHADEX-LH-20; methanol! to obtain 595 mg ofmethanesulfonic acid salt of the captioned compound (yield 46%, twosteps).

327 methanesulfonic acid salt

IR(KBr); ν 1736 cm⁻¹. Mass (FAB); m/z 503 (M+H)⁺

In accordance with Examples 13 and 14, by using17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan42,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylthio-6,7-2',3'-indolomorphinan12,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan121,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan76,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan3,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan77,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan119,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan46,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan7,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan47,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan127,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-cyano-6,7-2',3'-indolomorphinan52,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-cyano-6,7-2',3'-indolomorphinan8,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-cyano-6,7-2',3'-indolomorphinan53,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan189,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan6,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan188,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan190, 17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 64,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 9,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 65,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 131,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan66,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylamnino)methyl-6,7-2',3'-indolomorphinan10,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan67,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan130,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan175,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan174,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan173,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan78,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-nitro-6,7-2',3'-indolomorphinan79,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan136,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan114,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan22,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan115,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan138,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan84,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan26,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan85,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan 146,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-cyano-6,7-2',3'-indolomorphinan90,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-cyano-6,7-2',3'-indolomorphinan27,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-cyano-6,7-2',3'-indolomorphinan91,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan80,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylthio-6,7-2',3'-indolomorphinan31,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan81,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan140,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan191,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan25,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan192,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan193, 17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 102,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 28,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 103,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 150,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan104,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan29,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan105,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan149,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan178,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan177,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan176,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-nitro-6,7-2',3'-indolomorphinan116,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-nitro-6,7-2',3'-indolomorphinan117 or17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-nitro-6,7-2',3'-indolomorphinan155 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-methylthio-6,7-2',3'-indolomorphinan328,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-methylthio-6,7-2',3'-indolomorphinan329,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydtro-4,5α-epoxy-3-hydroxy-7'-methylthio-6,7-2',3'-indolomorphinan330,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan331,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan332,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan333,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan334,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan335,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan336,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan337,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan338,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-cyano-6,7-2',3'-indolomorphinan339,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-cyano-6,7-2',3'-indolomorphinan340,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-cyano-6,7-2',3'-indolomorphinan341,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan342,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan343,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan344,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan345,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 346,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 347,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 348,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 349,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan350,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan351,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan352,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan353,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan354,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan355, 14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan356,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-nitro-6,7-2',3'-indolomorphinan357,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-nitro-6,7-2',3'-indolomorphinan358,14β-acetoxy-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-nitro-6,7-2',3'-indolomorphinan359,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan360,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan361,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan362,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan363,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan364,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan365,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan366,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-(N-cyclopropylmethylcarbamoyl)-6,7-2',3'-indolomorphinan367,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-cyano-6,7-2',3'-indolomorphinan368,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-cyano-6,7-2',3'-indolomorphinan369,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-cyano-6,7-2',3'-indolomorphinan370,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-methylthio-6,7-2',3'-indolomorphinan371,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-methylthio-6,7-2',3'-indolomorphinan372,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-methylthio-6,7-2',3'-indolomorphinan373,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-methylthio-6,7-2',3'-indolomorphinan374,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-methylsulfonyl-6,7-2',3'-indolomorphinan375,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hiydroxy-5'-methylsulfonyl-6,7-2',3'-indolomorphinan376,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-methylsulfonyl-6,7-2',3'-indolomorphinan377,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-methylsulfonyl-6,7-2',3'-indolomorphinan378, 17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 379,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 380,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 381,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-2-(N,N-dimethylamino)ethyl)!-6,7-2',3'-indolomorphinan 382,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan383,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-5'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan384,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan385,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-(N,N-dimethylamino)methyl-6,7-2',3'-indolomorphinan386,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-isothiocyanato-6,7-2',3'-indolomorphinan387,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-isothiocyanato-6,7-2',3'-indolomorphinan388,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-isothiocyanato-6,7-2',3'-indolomorphinan389,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-4'-nitro-6,7-2',3'-indolomorphinan390,17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-6'-nitro-6,7-2',3'-indolomorphinan391 and17-allyl-14β-acetoxy-6,7-didehydro-4,5α-epoxy-3-hydroxy-7'-nitro-6,7-2',3'-indolomorphinan392 are obtained, respectively.

By using17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 2,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 401,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 402,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 403,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 404,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 405, 17-cyclopropylmethyl-314β-dihydroxy-4,5α-epoxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 406,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 407, 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 408,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 409,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 410,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-8'-sulfaamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 411 or17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 412 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 543,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 544,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 545,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 546,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 547,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 548,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 549,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 550, 14β-acetoxy-17-cyclopropylmethyl-⁴,5α-epoxy-3-hydroxy-9'-carbamoyl-6,7-didehydromorphinano 6,7-b!cyclohexenog!indole 551,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 552,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 553,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 554 and14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 555 are obtained, respectively.

By using17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromo:rphinano6,7-b!cyclohexeno e!indole 413,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 414,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 415,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 416,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole 417,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 418,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-diclehydromorphinano6,7-b!cyclohepteno e!indole 419,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 420,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 421,17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 422 or17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 423 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole 556,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 557,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 558,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 559,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole 560,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 56114β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole 562,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 563,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 564,14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 565 and14β-acetoxy-17-cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 566 are obtained, respectively.

By using 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 162,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 424,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,17-b!cyclohexeno g!indole 425,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 426,17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 427,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 428,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 429,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 430,17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 431,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 432,17-allyl-3,14β-dihydroxy-4,5α-epoxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 433,17-allyl-3,14β-dihydroxy-4,5α-epoxy-8'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 434 or17-allyl-3,14β-dihydroxy-4,5α-epoxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 435 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43, 14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 567,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 568,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-7'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 569,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-8'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 570,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-9'-ethoxycarbonyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 571,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 572,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-7'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 573,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-8'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 574,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-9'-carbamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 575,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 576,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-7'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 577,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-8'-sulfamoyl-6,7-didehydromorphinano6,17-b!cyclohexeno g!indole 578 and14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-9'-sulfamoyl-6,7-didehydromorphinano6,7-b!cyclohexeno g!indole 579 are obtained, respectively.

By using 17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole 436,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 437,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 438,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 439,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorl?hinano6,7-b!cyclopenteno f!indole 440,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 441,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole 442,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 443,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 444,17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 445 or17-allyl-3,14β-dihydroxy-4,5α-epoxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 446 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43, 14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno e!indole 580,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohexeno f!indole 581,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno g!indole 582,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno e!indole 583,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclopenteno f!indole 584,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno g!indole 585,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno e!indole 586,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cyclohepteno f!indole 587,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno g!indole 588,14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno e!indole 589 and14β-acetoxy-17-allyl-4,5α-epoxy-3-hydroxy-6,7-didehydromorphinano6,7-b!cycloocteno f!indole 590 are obtained, respectively.

Example 15

17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-propoxycarbonyl-6,7-2',3'-indolomorphinan393 ##STR28## In 9 ml of n-propanol, 517 mg (1.09 mmol) of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan77 was dissolved. To this solution, 11 ml of 1M sodium n-propoxidesolution in n-propanol was added and the resulting mixture was stirredat 60° C. for 2 hours. After cooling the reaction mixture to roomtemperature, 70 ml of water was added and the resultant was extractedwith 70 ml of chloroform and chloroform-methanol (3:1) 2×50 ml. Theorganic layers were combined, dried and concentrated to obtain 542 mg ofcrude product. The obtained crude product was purified by columnchromatography silica gel 30 g; hexane-ethyl acetate-methanol (7:7:1)!to obtain 490.6 mg (yield 90%) of the captioned compound. The obtainedcompound was dissolved in ethyl acetate and 0.065 ml of methanesulfonicacid solution in ethyl acetate was added thereto. The precipitates werecollected by filtration and washed with ethyl acetate to obtain 516.7 mg(yield 79%) of methanesulfonic acid salt of the captioned compound.

393 methanesulfonic acid salt

mp.: 175°-220° C. (decomposed). NMR (400 MHz, DMSO-d6); δ 0.44 (1H, m),0.50 (1H, m), 0.63 (1H, m), 0.73 (1H, m), 0.99 (3H, t, J=7.3 Hz), 1.09(1H, m), 1.74 (2H, tq, J=6.8, 7.3 Hz), 1.83 (1H, m), 2.30 (3H, s), 2.56(1H, d, J=16.1 Hz), 2.61 (1H, m), 2.72 (1H, m), 2.95 (1H, m), 2.99 (1H,d, J=16.1 Hz), 3.22 (1H, m), 3.26 (1H, dd, J=20.0, 6.8 Hz), 3.38 (1H,m), 3.45 (1H, d, J=20.0 Hz), 4.09 (1H, brd, J=6.3 Hz), 4.22 (2H, t,J=6.8 Hz), 5.74 (1H, s), 6.38 (1H, br s, OH), 6.60 (1H, d, J=8.1 Hz),6.64 (1H, d, J=8.1 Hz), 7.46 (1H, d, J=8.3 Hz), 7.61 (1H, dd, J=8.3, 1.5Hz), 8.07 (1H, br s), 8.94 (1H, m, NH⁺), 9.26 (1H, br s, OH), 11.76 (1H,s, NH). IR (KBr); ν 3422, 1688, 1638, 1626, 1508, 1462, 1330, 1212,1116, 1046, 872, 774 cm⁻¹. Mass (FAB); m/z 501 ((M+H)⁺). ElementaryAnalysis: C₃₀ H₃₂ N₂ O₅.CH₃ SO₃ H.0.6H₂ O; Calcd.:C, 61.29; H, 6.17; N,4.61; S, 5.28. Found :C, 61.06; H, 6.31; N, 4.64; S, 5.53.

By using17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan76,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan3,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan119,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methoxycarbonyl-6,7-2',3'-indolomorphinan114,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-ethoxycarbonyl-6,7-2',3'-indolomorphinan22,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,7-2',3'-indolomorphinan115 or17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-ethoxycarbonyl-6,7-2',3'-indolomorphinan138 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methoxycarbonyl-6,-2',3'-indolomorphinan77,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-propoxycarbonyl-6,7-2',3'-indolomorphinan394,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-propoxycarbonyl-6,7-2',3'-indolomorphinan395,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-propoxycarbonyl-6,7-2',3'-indolomorphinan396,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-propoxycarbonyl-6,7-2',3'-indolomorphinan397,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-propoxycarbonyl-6,7-2',3'-indolomorphinan398,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-propoxycarbonyl-6,7-2',3'-indolomorphinan399 and17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-propoxycarbonyl-6,7-2',3'-indolomorphinan400 are obtained, respectively.

Example 16

17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylsulfinyl-6,7-2',3'-indolomorphinan591, 592 ##STR29##

In 20 ml of acetic acid, 1.00 g of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan121 was dissolved. To this solution, a solution containing 0.45 g ofm-chloroperbenzoic acid (85%) in 10 ml of acetic acid was added dropwiseand the resulting mixture was stirred at room temperature for 1.5 hours.To this mixture, 1 ml of aqueous saturated sodium thiosulfate solutionwas added and the resulting mixture was stirred for 1 hour, followed byconcentration of the mixture. The obtained residue was neutralized byadding aqueous saturated sodium hydrogen carbonate solution and theresultant was extracted with chloroform:methanol (4:1). The organiclayers were washed with saturated saline, dried over anhydrous magnesiumsulfate and concentrated. The obtained residue was purified by columnchromatography silica gel; chloroform/methanol/28% aqueous ammonia(50:1:0.1-20:1:0.1)!. The low polar component was recrystallized frommethylene chloride:ethyl acetate and the high polar component wasrecrystallized from methylene chloride:methanol to obtain two types ofisomers 591 and 592 of the captioned compound in amounts of 306 mg and402 mg, respectively. These isomers were separately suspended inmethanol and equivalent methanesulfonic acid was added to thesuspensions to convert the compounds to salts. Each of the resultingmixtures was concentrated and excess ethyl acetate was added to theresidue. The obtained precipitates were collected. by filtration toobtain methanesulfonic acid salts in amounts of 337 mg (yield 27%) and463 mg (yield 37%), respectively.

591 free

mp.: 225°-227° C.

591 methanesulfonic acid salt

mp.: 230° C. (decomposed); NMR (500 MHz, DMSO-d6); δ 0.44 (1H, m), 0.50(11, m), 0.63 (1H, m), 0.74 (1H, m), 1.09 (1H, m), 1.85 (1H, br d,J=10.4 Hz), 2.30 (3H, s), 2.56 (1H, d, J=15.9 Hz), 2.60 (1H, m), 2.73(1H, m), 2.92 (3H, s), 2.94 (1H, m), 2.99 (1H, d, J=15.9Hz), 3.12 (1H,m), 3.26 (1H, dd, J=20.1, 6.7 Hz), 3.37 (1H,m), 3.45 (1H, J=19.5 Hz),4.09 (1H, d, J=6.1 Hz), 5.72 (1H, s), 6.38 (1H, s), 6.60 (1H, d, J=7.9Hz), 6.65 (1H, d, J=7.9 Hz), 7.18 (1H, dd, J=7.9, 7.3 Hz), 7.47 (1H, d,J=7.3 Hz), 7.56 (1H, d, J=7.9 Hz), 8.94 (1H, br s), 9.25 (1H, br s),11.66 (1H, s). IR (KBr); ν 3410, 1638, 1504, 1462, 1423, 1323, 1195,1060, 785, 561 cm⁻¹. Mass (FAB); m/z 477 (M+H). Elementary Analysis: C₂₇H₂₈ N₂ O₄ S.CH₃ SO₃ H.0.4H₂ O.0.2AcOEt; Calcd.:C, 57.89; H, 5.80; N,4.69; S, 10.73. Found :C, 58.16; H, 5.91; N, 4.66; S, 10.35.

592 free

mp.: 216°-218° C.

592 methanesulfonic acid salt

mp.: 240° C. (decomposed) NMR (500 MHz, DMSO-d6); δ 0.44 (1H, m), 0.50(1H, m), 0.63 (1H, m), 0.74 (1H, m), 1.10 (1H, m), 1.84 (1H, br d,J=11.0 Hz), 2.30 (3H, s), 2.57 (1H, d, J=15.9Hz), 2.60 (1H, m), 2.73(1H, m), 2.85 (3H, s), 2.94 (1H, m), 2.99 (1H, d, J=15.9Hz), 3.11 (1H,m), 3.26 (1H, dd, J=20.1, 6.7 Hz), 3.36 (1H,m), 3.45 (1H, J=19.5 Hz),4.09 (1H, d, J=6.1 Hz), 5.71 (1H, s), 6.37 (1H, br s), 6.60 (1H, d,J=7.9 Hz), 6.65 (1H, d, J=7.9 Hz), 7.22 (1H, dd, J=7.9, 7.3 Hz), 7.51(1H, d, J=7.3 Hz), 7.54 (1H, d,J=7.9 Hz), 8.94 (1H, br s), 9.24 (1H, brs), 11.71 (1H, s). IR (KBr); ν 3410, 1620, 1508, 1460, 1423, 1325, 1195,1060, 785, 561 cm⁻¹. Mass (FAB); m/z 477 (M+H). Elementary Analysis: C₂₇H₂₈ N₂ O₄ S.CH₃ SO₃ H.1.7H₂ O; Calcd.:C, 55.74; H, 5.91; N, 4.64; S,10.63. Found :C, 55.57; H, 5.87; N, 4.60; S, 10.76.

By using17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan42,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylthio-6,7-2',3'-indolomorphinan12,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan43,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylthio-6,7-2',3'-indolomorphinan80,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylthio-6,7-2',3'-indolomorphinan31,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylthio-6,7-2',3'-indolomorphinan81 or17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan140 in place of17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylthio-6,7-2',3'-indolomorphinan121,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylsulfinyl-6,7-2',3'-indolomorphinan593, 594,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfinyl-6,7-2',3'-indolomorphinan595, 596,17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylsulfinyl-6,7-2',3'-indolomorphinan597, 598,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-4'-methylsulfinyl-6,7-2',3'-indolomorphinan599, 600,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-5'-methylsulfinyl-6,7-2',3'-indolomorphinan601, 602,17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-6'-methylsulfinyl-6,7-2',3'-indolomorphinan603, 604, and17-allyl-6,7-didehydro-4,5α-epoxy-3,14β-dihydroxy-7'-methylsulfinyl-6,7-2',3'-indolomorphinan605, 606 are obtained, respectively.

The pharmacological effects of the compounds according to the presentinvention will now be described.

Example 17

<δ-opioid antagonist activity>

Using mouse vas deferens (MVD), the antagonist activity against DPDPEwhich is a δ-opioid agonist was checked.

Experimental Method

In this experiment, ddy male mice were used. In a Magnus' tube which isfilled with Krebes-Henseleit solution (NaCl 118 nM; KCl 4.7 mM; CaCl₂2.5 mM; KH₂ PO₄ 1.1 mM; NaHCO₃ 25 mM; glucose 11 mM) kept at 37° C., andinto which an atmosphere consisting of 5% carbon dioxide and 95% oxygenwas flown, vas deferens taken from the animals was suspended. Electricstimulation was applied through ring-shaped platinum electrodes mountedon the upper and lower portions of the tube at a frequency of 0.1 Hz and5.0 mS duration. The contraction of the tissue was recorded on polygraphusing isometric transducer.

First, DPDPE which is a δ-agonist was cumulatively added and IC₅₀ value(the concentration at which the contraction by the electric stimulationis inhibited by 50%) was calculated. Then 100 nM of the test compoundwas added. Twenty minutes later, DPDPE was begun to be addedcumulatively. The ratio of IC₅₀ values in the presence and absence ofthe test compound, Ke value (the molar concentration of the testcompound necessary for translating the dose-effect curve to the curve oftwice dose) and pA₂ value were determined. The pA₂ value was determinedby the method of Shild et al (Shild, H. O., Br. J. Pharmac. Chamotehr.,4, 277 (1949)). That is, the logarithm of the test compound (log testcompound!) was plotted along the abscissa and the logarithm of the valueobtained by subtracting 1 from the ratio of IC₅₀ values was plotted inthe presence and absence of the test compound log(dose ratio -1)! alongthe ordinate. The pA₂ value was determined from the value on theabscissa when the value on the ordinate of the obtained line is 0.

Results

The δ-antagonist activities of the principal compounds are shown inTables 1 and 2. All of the compounds have high antagonist activities. Inparticular, compounds 77, 119 and 190 exhibited activities as high asabout 1.3-1.6 times that of NTI (Ke: 0.21, pA₂ : 9.68) which is thecompound most widely used at present as a δ-antagonist. ##STR30##

                  TABLE 1                                                         ______________________________________                                        δ-opioid antagonist activities of indole compounds (1)                  Com-                       Ratio of                                           pound  R      R.sup.5      IC.sub.50 Values                                                                      Ke (nM)                                                                              pA.sub.2                            ______________________________________                                         1     CPM    5'-I         8.88    12.7   7.90                                 3     CPM    5'-CO.sub.2 C.sub.2 H.sub.5                                                                5.34    23.0   7.64                                 4     CPM    5'-OCF.sub.3 7.95    14.4   7.84                                 5     CPM    5'-SO.sub.2 NH.sub.2                                                                       4.36    29.8   7.53                                 6     CPM    5'-SO.sub.2 CH.sub.3                                                                       12.6    8.62   8.06                                 7     CPM    5'-CONH--CPM 33.2    3.11   8.51                                 8     CPM    5'-CN        3.60    38.5   7.41                                 9     CPM    5'-C.sub.2 H.sub.4 N(CH.sub.3).sub.2                                                       25.6    4.07   8.39                                10     CPM    5'-CH.sub.2 N(CH.sub.3).sub.2                                                              11.4    9.62   8.02                                40     CPM    4'-C.sub.2 H.sub.4 OH                                                                      4.60    27.8   7.56                                41     CPM    6'-C.sub.2 H.sub.4 OH                                                                      22.1    4.74   8.32                                43     CPM    6'-SCH.sub.3 168     0.60   9.22                                45     CPM    6'-SO.sub.2 NH--CPM                                                                        7.44    15.5   7.81                                46     CPM    4'-CONH--CPM 1.39    256    6.59                                47     CPM    6'-CONH--CPM 13.0    8.33   8.08                                48     CPM    4'-CH.sub.2 CO.sub.2 C.sub.2 H.sub.5                                                       5.88    20.5   7.69                                49     CPM    6'-CH.sub.2 CO.sub.2 C.sub.2 H.sub.5                                                       27.8    3.73   8.43                                51     CPM    6'-SO.sub.2 N(CH.sub.3).sub.2                                                              33.2    3.11   8.57                                53     CPM    6'-CN        62.3    1.63   8.79                                76     CPM    4'-CO.sub.2 CH.sub.3                                                                       6.82    17.2   7.76                                77     CPM    6'-CO.sub.2 CH.sub.3                                                                       742     0.13   9.87                                78     CPM    4'-NO.sub.2  14.8    7.25   8.14                                79     CPM    6'-NO.sub.2  60.6    1.68   8.78                                114    allyl  4'-CO.sub.2 CH.sub.3                                                                       20.7    5.08   8.29                                115    allyl  6'-CO.sub.2 CH.sub.3                                                                       75.4    1.34   8.87                                118    CPM    7'-CF.sub.3  52.9    1.93   8.72                                119    CPM    7'-CO.sub.2 C.sub.2 H.sub.5                                                                635     0.16   9.80                                120    CPM    7'-Ph        17.0    6.25   8.20                                121    CPM    7'-SCH.sub.3 33.6    3.07   8.51                                136    CPM    7'-NO.sub.2  192     0.52   9.28                                180    CPM    5'-CH.sub.2 NH--CPM                                                                        15.2    7.04   8.15                                188    CPM    6'-SO.sub.2 CH.sub.3                                                                       56.0    1.82   8.74                                190    CPM    7'-SO.sub.2 CH.sub.3                                                                       698     0.14   9.84                                393    CPM    6'-CO.sub.2 C.sub.3 H.sub.7                                                                12.3    8.85   8.05                                ______________________________________                                    

In the table, CPM means crclopropylmethyl group. ##STR31##

                  TABLE 1                                                         ______________________________________                                        δ-antagonist activities of Indole Compounds (1)                         Com-                       Ratio of                                           pound  R      R.sup.5      IC.sub.50 Values                                                                      Ke (nM)                                                                              pA.sub.2                            ______________________________________                                        118    CPM    7'-CF.sub.3  52.9    1.93   8.72                                119    CPM    7'-CO.sub.2 C.sub.2 H.sub.5                                                                635     0.16   9.80                                120    CPM    7'-Ph        17.0    6.25   8.20                                121    CPM    7'-SCH.sub.3 33.6    3.07   8.51                                136    CPM    7'-NO.sub.2  192     0.52   9.28                                180    CPM    5'-CH.sub.2 NHCPM                                                                          15.2    7.04   8.15                                188    CPM    6'-SO.sub.2 CH.sub.3                                                                       56.0    1.82   8.74                                190    CPM    7'-SO.sub.2 CH.sub.3                                                                       698     0.14   9.84                                393    CPM    6'-CO.sub.2 C.sub.3 H.sub.7                                                                12.3    8.85   8.05                                ______________________________________                                    

In the table, CPM means cyclopropylmetlhyl group.

                                      TABLE 2                                     __________________________________________________________________________    antagonist Activities of Indole Compounds (2)                                       Structural                  Ratio of IC.sub.50                          Compound                                                                            Formula                     Values                                                                              Ke(nM)                                                                            pA.sub.2                          __________________________________________________________________________           ##STR32##                  22.1  4.74                                                                              8.32                              156                                                                                  ##STR33##                  26.6  3.91                                                                              8.41                              __________________________________________________________________________

Example 18

<Change in δ-antagonist activity with time>

Using MVD, the antagonist activities of compounds 173 and 174 againstDPDPE were determined. The ratio of IC₅₀ values, Ke values and pA₂values at 15 minutes, 30 minutes and 1 hour from the addition of thetest compounds were calculated. The results are shown in Table 3 andFIGS. 1 and 2. Since the concentrations of the test compounds aredifferent, the reciprocals of Ke values were plotted in FIGS. 1 and 2.

While the activity of NTI did not change, the antagonist activities ofcompounds 173 and 174 and 5'-NTII increased with time. The increase inthe activity is due to irreversible binding to the receptors. Althoughboth compounds 173 and 174 are isomers of 5'-NTII, their activities werehigh. That is, compound 173 exhibited an activity at 1 hour of about 3.5times that of NTI and about 170 times that of 5'-NTII, and compound 174exhibited an activity at 1 hour of about 7 times that of 5'-NTII. Thus,although the activity of compound 173 is inferior to that of compound174, the activities of these compounds are drastically higher than thoseof the conventional antagonists.

As mentioned above, a large part of the various pharmacological actionsof δ-opioid receptor has not yet been clarified. The compounds of thepresent invention have very high activities and selectivities, whichirreversibly bind to δ-opioid receptor, so that they would be veryuseful in the future studies of opioids. ##STR34##

                  TABLE 3                                                         ______________________________________                                        Change with Time of δ-antagonist Activities of                          Indole Compounds                                                                               Time     Ratio of                                            Compound R.sup.5 (min.)   IC.sub.50 Values                                                                      Ke (nM)                                                                              pA.sub.2                             ______________________________________                                        173      7'-NCS  15       105     0.19   9.72                                 (20 nM)          30       253     0.08   10.1                                                  60       306     0.07   10.2                                 174      6'-NCS  15       25.7    4.05   8.39                                 (100 nM)         30       47.6    2.15   8.67                                                  60       58.6    1.74   8.76                                 5'-NTII  5'-NCS  15       3.28    43.9   7.36                                 (100 nM)         30       7.47    15.5   7.81                                                  60       9.36    12.0   7.92                                 NTI      H       15       96.3    0.21   9.68                                 (20 nM)          30       95.6    0.21   9.67                                                  60       83.7    0.24   9.62                                 ______________________________________                                    

Example 19

<κ-opioid antagonist activity>

Using guinea pig ileum (GPI), antagonist activities against U-50488Hwhich is a κ-opioid agonist was determined.

Experimental Method

Hartley male guinea pigs were used. After killing the guinea pigs byclubbing, ilea were taken. The inside of the ilea was washed with anutrient liquid and only longitudinal muscles were peeled off. Using thethus obtained longitudinal muscles, the tests were carried out using thesame apparatus as used in the experiment employing MVD.

First, U-50488H which is a κ-agonist was cumulatively added and IC₅₀value was determined. Thereafter, the muscle was well washed with thenutrient liquid. After the contraction reaction became stable, 100 nM ofa test compound was added. From 20 minutes after, U-50488H wascumulatively added and the ratio of IC₅₀ values, Ke value and pA₂ valuewere determined in the same manner as in the experiment employing MVD.

Results

Although most of the compounds did not exhibit agonist activities orantagonist activities, the five compounds shown in Table 4 exhibitedstrong κ-antagonist activities. These compounds also have δ-antagonistactivities. A compound having both δ- and κ-antagonist activities arenot known, so that it is expected that these compounds will be effectivefor clarifying unknown actions of opioids and relationships betweenδ-receptor and κ-receptor. ##STR35##

                  TABLE 4                                                         ______________________________________                                        κ-antagonist Activities of Indole Compounds                             Com-                       Ratio of                                           pound R.sup.1 R.sup.5      IC.sub.50 Values                                                                      Ke (nM)                                                                              pA.sub.2                            ______________________________________                                         7    CPM     5'-CONH--CPM 22.8    4.59   8.34                                 9    CPM     5'-C.sub.2 H.sub.4 N(CH.sub.3).sub.2                                                       99.0    4.07   8.39                                10    CPM     5'-CH.sub.2 N(CH.sub.3).sub.2                                                              19.4    9.67   8.02                                45    CPM     6'-SO.sub.2 NH--CPM                                                                        3.22    45.1   7.35                                47    CPM     6'-CONH--CPM 3.11    47.4   7.32                                ______________________________________                                    

In the table, CPM means cyclopropylmethyl group.

It is known that κ-opioid receptor relates to diuresis and protection ofbrain cells. The present inventors have already proved that nor-BNIwidely known as κ-antagonist has brain cell-protecting action (JapaneseLaid-open Patent Application (Kokai) No. 3-218313). Since the compoundsof the invention are also κ-antagonists, it is expected that thesecompounds have the same actions. Thus, these compounds were tested forthe brain cell-protecting actions.

Example 20

<Brain cell-protecting action>

The brain cell-protecting action was examined by MTT3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide! method.MTT yields a dark blue formazan compound by mitochondria in livingcells. This compound was dissolved in isopropanol and absorbance at 570nm was measured, thereby measuring the number of living cells.

Experimental Method

Cerebral cortex nerve cells of fetal rats of 17 days old were placed inwells of a 96-well plate at a population density of 1×10⁵ cells/cm².Then 10 μM of a test compound was added and the cells were cultured in200 μl of mixed medium of D-MEM/F.12 (1:1) for 3 days (37° C., 5%CO₂).In a control group, the medium alone was added. Then 10 μl of MTTsolution in PBS (6 mg/ml) was added and the mixture was allowed to reactfor 3 hours (37° C., 5% CO₂). After removing the culture medium, 100 μlof isopropanol was added and the absorbance was measured.

Results

The ratio of the absorbances of the study group and the control groupwas employed as an index of brain cell-protecting action. The resultsare shown in Table 5. Clear activities were observed with compounds 7,9, 10 and 180. In particular, compounds 9 and 180 exhibited activitieshigher than that of nor-BNI. In view of the fact that while theκ-antagonist activities of the compounds of the present invention arelower than that of nor-BNI, the compounds of the present invention havesuperior brain cell-protecting action than nor-BNI, and that NTI whichis a δ-opioid antagonist has brain cell-protecting action, it issuggested that the compounds having antagonist activities for both δ-and κ-receptors are superior as brain cell-protecting agents. ##STR36##

                  TABLE 5                                                         ______________________________________                                        Brain Cell - Protecting Actions of Indole Compounds                                                            Ratio of                                     Compound  R.sup.1   R.sup.5      Absorbances                                  ______________________________________                                         7        CPM       5'-CONH--CPM 5.31                                          9        CPM       5'-C.sub.2 H.sub.4 N(CH.sub.3).sub.2                                                       8.27                                         10        CPM       5'-CH.sub.2 N(CH.sub.3).sub.2                                                              7.58                                         180       CPM       5'-CH.sub.2 NH--CPM                                                                        8.73                                         NTI       CPM       H            4.21                                         nor-BNI                          7.60                                         ______________________________________                                    

In the table, CPM means cyclopropylmethyl group.

Example 21

<Immunosuppressive Activity>

The immunosuppressive activities of the compounds of the presentinvention were examined by suppression of mouse delayed typehypersensitivity.

Mouse Delayed Type Hypersensitivity Reaction Suppression Test -1

Experimental Method

BALB/c mice (male, 7 weeks old) were used. The mice were classified intogroups depending on the body weight, each group consisting of 7-8 mice.Each of the mice was sensitized by subcutaneously administering 25 μl ofSRBC (8×10⁸ in saline) on the heel of the left hing leg. On day 4 fromthe sensitization, 25 μl of SRBC (8×10⁹ in saline) was subcutaneouslyadministered on the right footpad so as to induce delayed typehypersensitivity. The difference in the thicknesses of the right footpadbefore the induction of reaction and 24 hours after the induction of thereaction was employed as an index of the degree of the reaction.

The test compound was dissolved in 10% DMSO-water and was subcutaneouslyadministered everyday from 3 days before the sensitization to the day ofinduction of the reaction, totally 8 days. In the control group, 10%DMSO-water alone was administered in the same manner. The volume ofadministration was 5 ml/kg in both study groups and in the controlgroup.

The % suppression of the delayed type hypersensitivity reaction wascalculated according to the following equation: ##EQU1## wherein A meansthe difference in the thickness of the right hind leg before and afterthe reaction in control group, and B means the difference in thethickness of the right hind leg before and after the reaction in thegroup to which the test compound was administered.

Results

The compounds which exhibited suppressive actions and their suppressionrates are shown in Table 6. ##STR37##

                  TABLE 6                                                         ______________________________________                                        Suppression of Delayed Type Hypersensitivity                                  by Indole Compounds                                                           Compound  R.sup.1   R.sup.5   % Suppression                                   ______________________________________                                         43       CPM       6'-SCH.sub.3                                                                            26                                               53       CPM       6'-CN     18                                               78       CPM       4',-NO.sub.2                                                                            36                                              119       CPM       7'-CO.sub.2 C.sub.2 H.sub.5                                                             12                                              121       CPM       7'-SCH.sub.3                                                                            20                                              136       CPM       7'-NO.sub.2                                                                             18                                              NTI       CPM       H         did not suppress                                CsA                           50                                              ______________________________________                                    

In the table, CPM means cyclopropylmethyl group.

No δ-opioid antagonists which suppress the delayed type hypersensitivityreaction are known, so that it was proved that the compounds areδ-opioid antagonists having a novel action. While the currently usedimmunosuppressants represented by cyclosporin A (CyA) suppresses thereaction by being administered after the sensitization, the compounds ofthe present invention exhibit the suppressive activity by beingadministered from before the sensitization. This means that thecompounds of the present invention act through a mechanism which isdifferent from that of the conventional drugs, so that it is suggestedthat there is a possibility that the compounds of the present inventionare immunosuppressants of totally new type.

Example 22

Mouse Delayed Type Hypersensitivity Reaction Suppression Test-2

Experimental Method

BALB/c mice (male, 7 weeks old) were used, and each group consisted of4-5 mice. Spleen cells (1×10⁷) obtained from a donor mouse (C57BL/6) wassubcutaneously administered to sensitize the mice. On Day 7 from thesensitization, the spleen cells (5×10⁶) of the donor were subcutaneouslyadministered on the right hing leg and spleen cells (5×10⁶) obtainedfrom a mouse of the same line as the recipient mice were subcutaneouslyadministered on the left footpad. Twenty four hours later, thethicknesses of the right and left footpads were measured with a dialthickness gage, and the difference in thicknesses of the right and leftfootpads before the induction of the reaction and 24 hours after theinduction of the reaction was employed as the index of the degree of thereaction.

The test compound was dissolved in 10% DMSO-water and was subcutaneouslyadministered everyday from the day of sensitization to the day ofinduction of the reaction, totally 8 days. In the control group, 10%DMSO-water alone was administered in the same manner. The volume ofadministration was 10 ml/kg in both study groups and in the controlgroup. Delayed Type Hypersensitivity Reaction=(thickness of rightfoodpad after induction-thickness of right footpad beforeinduction)-(thickness of right footpad after induction-thickness ofright foodpad leg before induction) ##EQU2## wherein C means delayedtype hypersensitivity reaction of the group to which the test compoundwas administered and D means the delayed type hypersensitivity reactionof the group to which vehicle was administered.

Results

The compounds which exhibited suppressive activities and their %suppression are shown in Table 7. ##STR38##

                  TABLE 7                                                         ______________________________________                                        Suppression of Delayed Type Hypersensitivity                                  by Indole Compounds (2)                                                       Compound R.sup.1 X         Y       % Suppression                              ______________________________________                                         2       CPM     --(CH.sub.2).sub.4 --                                                                         60                                            43      CPM     SCH.sub.3 H       27                                         119      CPM     H         CO.sub.2 C.sub.2 H.sub.5                                                              31                                         120      CPM     H         Ph      46                                         393      CPM     CO.sub.2 C.sub.3 H.sub.7                                                                H       33                                         591      CPM     H         SOCH.sub.3                                                                            16                                         592      CPM     H         SOCH.sub.3                                                                            20                                         NTI      CPM     H         H       60                                         CsA                                32                                         ______________________________________                                    

In the table, CPM means cyclopropylmethyl group.

Example 23

Mouse Delayed Type Hypersensitivity Reaction Suppression Test-3

Experimental Method

BALB/c mice (male, 7 weeks old) were used, and each group consisted of4-5 mice. Spleen cells (1×10⁷) obtained from a donor mouse (C57BL/6) wassubcutaneously administered to sensitize the mice. On Day 7 from thesensitization, the spleen cells (5×10⁶) of the donor were subcutaneouslyadministered on the right footpad and spleen cells (5×10⁶) obtained froma mouse of the same strain as the recipient mice were subcutaneouslyadministered on the left footpad. Twenty four hours later, thethicknesses of the right and left footpads were measured with a dialthickness gage, and the difference in thicknesses of the right and leftfootpads before the induction of the reaction and 24 hours after theinduction of the reaction was employed as the index of the degree of thereaction.

The test compound was dissolved in water and 5×10⁻⁸ mol/mouse wasadministered into cerebral ventricles. In the control group, water alonewas administered similarly. The dose was 5 μl/mouse in both the studygroups and the control group.

Results

The results are shown in Table 8.

                                      TABLE 8                                     __________________________________________________________________________    Suppression of Delayed Type Hypersensitivity by Indole Compounds (3)                Structural                                                              Compound                                                                            Formula                     % Suppression                               __________________________________________________________________________           ##STR39##                  83                                          NTI                                                                                  ##STR40##                  40                                          __________________________________________________________________________

By administration through cerebral ventricle, suppressive activity wasobserved, so that it was proved that these compounds suppress immunethrough the central nerve. Particularly, compound 2 according to thepresent invention exhibited suppressive effect far stronger than NTI, sothat it was found that this is a strong immunosuppressant which actsthrough different mechanism from that of the conventional drugs.

Example 24

The mechanism of immunosuppression of the compound of the presentinvention was examined using delayed type hypersensitivity suppressiontest using mice from which adrenal glands have been removed.

Experimental Method

BALB/c mice (male, 7 weeks old) were used, and each group consisted of4-5 mice. Spleen cells (1×10⁷) obtained from a donor mouse (C57BL/6) wassubcutaneously administered to sensitize the mice. On Day 7 from thesensitization, the spleen cells (5×10⁶) of the donor were subcutaneouslyadministered on the right footpad and spleen cells (5×10⁶) obtained froma mouse of the same strain as the recipient mice were subcutaneouslyadministered on the left footpad. Twenty four hours later, thethicknesses of the right and left footpads were measured with a dialthickness gage, and the difference in thicknesses of the right and leftfootpads before the induction of the reaction and 24 hours after theinduction of the reaction was employed as the index of the degree of thereaction.

The adrenectomy was performed by cutting the back of each recipientmouse under anesthesia with ether before the sensitization and removingthe adrenal gland. Sham operation was performed by cutting the back ofeach recipient mouse but not removing the adrenal gland.

The test compound was dissolved in 10% DMSO-water and was subcutaneouslyadministered everyday from the day of sensitization to the day ofinduction of the reaction, totally 8 days. In the control group, 10%DMSO-water alone was administered in the same manner. The volume ofadministration was 10 ml/kg in both study groups and in the controlgroups.

Results

The results are shown in Table 9.

                                      TABLE 9                                     __________________________________________________________________________    Suppression of Delayed Type Hypersensitivity                                  by Indole Compounds (4)                                                                                         % Suppression                                     Structural                  Sham                                        Compound                                                                            Formula                     Operation                                                                          Adrenectomy                            __________________________________________________________________________           ##STR41##                  60   60                                     NTI                                                                                  ##STR42##                  50   0                                      __________________________________________________________________________

While the suppressive effect of NTI disappeared by removing adrenalgland, the suppressive effect of compound 2 was not lost by removingadrenal gland. Thus, it was shown that the mechanisms of action of thesecompounds are clearly different.

Delayed type hypersensitivity reaction relates to rejection during organtransplantations and allergy. Since the compound of the presentinvention suppresses this reaction, it can be used for suppressing therejection during organ transplantations. Further, the compound has wideuses such as antiallergic agent and anti-inflammatory agent.

Example 25

Mouse Contact Dermatitis Suppression Test

Experimental Method

BALB/c mice (male, 13-15 weeks old) were used, and each group consistedof 4 mice. In mixed liquid of acetone: olive oil=4:1,2,4-difluorobenzene (DNFB) was dissolved. On Day 0 and Day 1, 0.1% DNFB(50 μl) was sensitized to the clipped skin of the abdominal wall, so asto sensitize the mouse. On day 5, 0.15% DNFB (25 μl/ear) was challengedon closal side of each ear love of each mouse, so as to induce thereaction. The compound was administered into cerebral ventricle 30minutes before the induction.

The contact dermatitis was detected in terms of the increase in thethicknesses of the ears. The thicknesses of the ears were measuredbefore and 24 hours after the challenge by using a dial thickness gage.One ear was taken as n=1, and the increase in the thickness of the earwas used as an index for detecting the contact dermatitis. ContactDermatitis=(thickness of the ear after challenge)-(thickness of the earbefore challenge) ##EQU3## wherein E means the contact dermatitis of thegroup to which the compound was administered, and F means the contactdermatitis of the group to which the vehicle was administered.

Results

Compound 2 of the present invention exhibited suppression of 44%, sothat it was shown that this compound is effective for allergicdermatitis.

We claim:
 1. An indole derivative represented by the formula (I):##STR43## wherein R¹ represents cyclopropylmethyl or allyl; R²represents hydrogen, hydroxy, C₁ -C₅ alkanoyloxy or C₁ -C₅ alkoxy;R³represents hydrogen, C₁ -C₅ alkyl, C₁ -C₅ alkanoyl or benzyl; R⁴represents hydrogen, C₁ -C₅ alkyl or benzyl; R⁵ represents (CH₂)_(n) NR⁸R⁹ or CONR⁸ R⁹ wherein n represents an integer of 1-3, R⁸ and R⁹ are thesame or different and represent C₁ -C₅ alkyl, or C₄ -C₆ cycloalkylalkyland R⁶ represents hydrogen or pharmaceutically acceptable acid additionsalts thereof.
 2. A process for producing the indole derivative or thepharmaceutically acceptable acid addition salt thereof according toclaim 1, comprising the step of reacting a compound of the formula(III): ##STR44## (wherein R¹, R² and R³ represent the same meanings asdescribed above, respectively)with a phenylhydrazine derivative of theformula (IV): ##STR45## (wherein R⁴, R⁵ and R⁶ represent the samemeanings as described above, respectively) in the presence of an acidcatalyst selected from the group consisting of hydrochloric acid,sulfuric acid, nitric acid, phosphoric acid, methanesulfonic acid,p-toluenesulfonic acid, acetic acid, formic acid and propionic acid. 3.A pharmaceutical composition comprising an effective amount of theindole derivative or the pharmaceutically acceptable acid addition saltthereof according to claim 1; and a pharmaceutically acceptable carrier.